Experiences with Leukocyte Adherence Inhibition in Human Cancer

Abstract

The original hemocytometer leukocyte adherence inhibition technique has been used to study immunological reactivity of patients with a variety of tumors. Cellular activity was closely correlated with exposure to tumor of the appropriate type. Specificity and sensitivity in terms of having few false positives and false negatives were of the order of 90% or greater, and repeated testing of the same patients showed a high degree of reproducibility. Patients with tumors showed specific leukocyte reactivity at all stages of tumor growth, and there was no “eclipse” phase even in very advanced disease