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research
Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts
Authors
J W Ballard
N Braidy
+9 more
Daniel K Y Chan
B H Chong
Z M Fang
Wei Ping Gai
G J Guillemin
M P Horan
X M Jiang
Perminder Sachdev
Y H Xu
Publication date
1 January 2013
Publisher
'Springer Science and Business Media LLC'
Doi
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on
PubMed
Abstract
© 2013 Braidy et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson’s disease (PD). In this study, we show that α-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblasts in vitro. Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function, leading to cellular degeneration and cell death, provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells
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