Protective effect of NSAIDs on cancer and influence of COX-2 C-765G genotype

Coebergh, J.W.W. (Jan Willem); Hofman, A. (Albert); Siemes, C. (Claire); Stricker, B.H.Ch. (Bruno); Uitterlinden, A.G. (André); Visser, L.E. (Loes)

Protective effect of NSAIDs on cancer and influence of COX-2 C-765G genotype

Authors: J.W.W. (Jan Willem) Coebergh
A. (Albert) Hofman
C. (Claire) Siemes
B.H.Ch. (Bruno) Stricker
A.G. (André) Uitterlinden
L.E. (Loes) Visser
Publication date: 1 December 2008
Publisher: 'Bentham Science Publishers Ltd.'
Doi

Abstract

Purpose: Inhibition of COX-2 enzymes is a frequently suggested mechanism for the beneficial effects of NSAIDs on carcinogenesis. The aim of this study was to explore the role of cumulative NSAID use on four common non-skin related cancers and modification by COX-2 G-765C genotype. Patients and methods: 7621 participants of The Rotterdam Study were included. In a mean follow up period of 10 years, 720 color

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