research
Percutaneous Coronary Interventions in Stable and Acute Coronary Syndromes: Stent technology, lesion complexity and clinical outcome
- Publication date
- 20 January 2015
- Publisher
- __Abstract__
Percutaneous coronary intervention (PCI) has brought a major revolution in the way
we manage coronary artery disease. Since the first intervention by Andreas Grüntzig in
1977, development of the technology has been relentless and today PCI has been
established as one of the major pillars of treatment of coronary heart disease alongside
its medical and surgical solutions.
Stent implantation during PCI has given the needed edge to PCI, not only in restoring
coronary flow but moreover in maintaining it.
The aim of this thesis were to :
1. Determine the long term outcome of drug eluting stent implantation compared
to bare metal stents in the general PCI population and explore clinical benefits of
newer generation drug eluting stents.
2. Examine the clinical outcome of drug eluting stents in patient populations prone to
aggressive coronary artery disease.
3. Analyse determinants and prognostic value of myocardial no reflow after stenting in
acute myocardial infarction.
4. Utilize OCT to gain further insights into intra coronary thrombus and the effects for
stenting and thrombectomy in patients with STEMI.
5. Establish the usefulness of the Syntax score in risk stratification of patients presenting
with ST elevation myocardial infarction.
6. Assess the outcome of drug-eluting stent implantation in bypass grafts and evaluate
a dedicated stent developed for bifurcation stenting including that of the left main
stem.