__Abstract__



The liver is the second largest organ in the body, only after the skin. The liver is a roughly triangular organ that extends across the entire abdominal cavity just inferior to the diaphragm. It consists of 4 distinct lobes – the left, right, caudate, and quadrate lobes. It is one of the organs that can regenerate. The liver plays an active role in the process of digestion through the production of bile, which helps carry away waste and break down fats in the small intestine during digestion. The other well-known functions of the liver are production of cholesterol, production of certain proteins for blood plasma, conversion of excess glucose into glycogen for storage. It also regulates blood clotting and blood levels of amino acids

Ramakrishnaiah, V. (Vedashree)

Ramakrishnaiah, Veda

EUR Research Repository

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On the Release of Small RNAs and Viruses from Hepatocytes

__Abstract__
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\nThe liver is the second largest organ in the body, only after the skin. The liver is a roughly triangular organ that extends across the entire abdominal cavity just inferior to the diaphragm. It consists of 4 distinct lobes \xe2\x80\x93 the left, right, caudate, and quadrate lobes. It is one of the organs that can regenerate. The liver plays an active role in the process of digestion through the production of bile, which helps carry away waste and break down fats in the small intestine during digestion. The other well-known functions of the liver are production of cholesterol, production of certain proteins for blood plasma, conversion of excess glucose into glycogen for storage. It also regulates blood clotting and blood levels of amino acids

Erasmus University Digital Repository

PROPOSITIONS TO THE TI-ll-iSIS "On the release of small RNAs and viruses from hepatocytes" 13Y VHDASHREE RAMAKRISHNAIAH I . Human and mouse hepatoeytes have both the ability to release small RNAs and the ability to lake them up from the extracellular environment. (This thesi.1) 2. Hepatic mieroRNAs released into blood have the potential as early and sensitive biomarkers of hepatocyte injury after liver transplantation. (This thesis) 3. The release of microRNA from hepatocytes is bi-directional with controlled secretion into bile being associated with good liver graft function. (This thesis) 4. Hepatocyte-derived exosomes can transmit hepatitis C virus infection from one cell to another. (This thesis) 5. Transmission of infection for the hepatitis C virus still is not fully elucidated, but could involve a fecal route through viral release in bile. (This thesi.~) 6. RNAi represents a feasible and promising future treatment strategy for special populations infected with HCV who have poor tolerability to standard therapy or are non-responders. (This thesis) 7. One of the most intriguing roles of exosomes is intercellular communication-they arc thought to function as the messengers, delivering various effectors or signaling macromolecules between specific cells. Biochim Biophys Acta. 2012 Jul; 1820(7):940-8 8. MiRNAs are a promising new therapeutic target to prevent and restore ischemia and reperfusion injury after transplantation. Plos One. 2013 Nov 20;8(11):e79805. 9. It has been said that the primary function of schools is to impart enough facts to make children stop asking questions. Some, with whom the schools do not succeed, become scientists . ~ Knut Schmidt-Nielson. 10. "Science, my lad, is made up of mistakes, but they are mistakes which it is useful to make, because they lead little by little to the truth." -Jules Verne, A Journey to the Center of the Earth. I I. "Friendship is the source of the greatest pleasures, and without friends even the most agreeable pursuits become tedious."- Thomas Aquinas 

On the release of small RNAs and viruses from hepatocytes

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