Aims: We sought to evaluate the prognostic impact of age on the procedural results and subsequent clinical outcomes in patients with multivessel disease (MVD) treated either by coronary artery bypass surger

Endersen, K. (Knut)

Fontanelli, A. (Alessandro)

Garg, S.A. (Scot)

Kranjec, I. (Igor)

Legrand, V.M.G. (Victor)

Rademaker, T.A.M. (Tessa)

Serruys, P.W.J.C. (Patrick)

Stefanidis, C.I. (Christodoulos)

Szurawitzki, G. (Günter)

Virtanen, K.S. (Kari)

Voudris, V.

Wittebols, K. (Kristel)

peer reviewedAims: We sought to evaluate the prognostic impact of age on the procedural results and subsequent clinical
outcomes in patients with multivessel disease (MVD) treated either by coronary artery bypass surgery (CABG) or
by percutaneous coronary intervention (PCI) with or without drug eluting stents, based on data of the Arterial
Revascularisation Therapies Study (ARTS) part I and part II. The potential influence of age in determining the most
appropriate revascularisation strategy for patients with MVD is largely unknown.
Methods and results: Three year clinical outcome of ARTS I patients randomised to PCI with bare metal stent
(BMS) (n= 600) or CABG (n= 605), and matched patients treated by PCI with sirolimus-eluting stents (SES) in
ARTS II (n= 607) were reviewed according to four age quartiles. Endpoints were measured in terms of major
adverse cardiac and cerebrovascular events MACCE) during hospital stay and up to three years. The frequency of
female, diabetes, hypertension, peripheral vascular disease, pulmonary disease, as well as lesion complexity
increased with age. At three years, MACCE free survival was comparable between patients treated by CABG or
SES PCI, regardless of age quartile. The incidence of MACCE was higher among ARTS I BMS treated patients in
all but the second age quartile. This was primarily related to a higher need for repeat revascularisation among BMS
treated patients. However, age, which emerged as a strong independent predictor of MACCE following CABG
(p<0.005), was not predictive of adverse events following PCI. Conversely, diabetes was the strongest independent
predictor of MACCE among PCI treated patients (p<0.02), but didn’t affect three-year outcomes following CABG.
Conclusions: Age seems to influence the CABG outcome in-hospital but not PCI. PCI-SES could offer lower
immediate risk in patients with MVD and comparable long-term outcome as CABG especially in older patients.
The worst outcome of PCI-BMS group is primarily related to the need for repeat revascularisation. Diabetes is the
most important predictor of MACCE following PCI

Legrand, Victor

Garg, Scott

Serruys, Patrick

Virtanen, Kari

Szurawitzki, Günter

Voudris, Vassilis

Fontanelli, Alessandro

Endersen, Knut

Kranjec, Igor

Rademaker, Tessa

Stefanidis, Christodoulos

Wittebols, Kristel

Open Repository and Bibliography - Liège

Influence of age on the clinical outcomes of coronary revascularisation for the treatment of patients with multivessel de novo coronary artery lesions: sirolimus-eluting stent vs. coronary artery bypass surgery and bare metal stent, insight from the multicentre randomised Arterial Revascularisation Therapy Study Part I (ARTS-I) and Part II (ARTS-II)

Aims: We sought to evaluate the prognostic impact of age on the procedural results and subsequent clinical outcomes in patients with multivessel disease (MVD) treated either by coronary artery bypass surgery (CABG) or by percutaneous coronary intervention (PCI) with or without drug eluting stents, based on data of the Arterial Revascularisation Therapies Study (ARTS) part land part II. The potential influence of age in determining the most appropriate revascularisation strategy for patients with MVD is largely unknown. Methods and results: Three year clinical outcome of ARTS I patients randomised to PCI with bare metal stent (BMS) (n= 600) or CABG (n= 605), and matched patients treated by PCI with sirolimus-eluting stents (SES) in ARTS II (n= 607) were reviewed according to four age quartiles. Endpoints were measured in terms of major adverse cardiac and cerebrovascular events MACCE) during hospital stay and up to three years. The frequency of female, diabetes, hypertension, peripheral vascular disease, pulmonary disease, as well as lesion complexity increased with age. At three years, MACCE free survival was comparable between patients treated by CABG or SES PCI, regardless of age quartile. The incidence of MACCE was higher among ARTS I BMS treated patients in all but the second age quartile. This was primarily related to a higher need for repeat revascularisation among BMS treated patients. However, age, which emerged as a strong independent predictor of MACCE following CABG (p&lt;0.005), was not predictive of adverse events following PCI. Conversely, diabetes was the strongest independent predictor of MACCE among PCI treated patients (p&lt;0.02), but didn&apos;t affect three-year outcomes following CABG. Conclusions: Age seems to influence the CABG outcome in-hospital but not PCI. PCI-SES could offer lower immediate risk in patients with MVD and comparable long-term outcome as CABG especially in older patients. The worst outcome of PCI-BMS group is primarily related to the need for repeat revascularisation. Diabetes is the most important predictor of MACCE following PCI

Legrand, VM

Garg, Scot

Serruys, PWJC (Patrick)

Virtanen, KS

Szurawitzki, G

Voudris, V

Fontanelli, A

Endersen, K

Kranjec, I

Rademaker, T

Stefanidis, CI

Wittebols, K

EUR Research Repository

Aims: We sought to evaluate the prognostic impact of age on the procedural results and subsequent clinical outcomes in patients with multivessel disease (MVD) treated either by coronary artery bypass surgery (CABG) or by percutaneous coronary intervention (PCI) with or without drug eluting stents, based on data of the Arterial Revascularisation Therapies Study (ARTS) part land part II. The potential influence of age in determining the most appropriate revascularisation strategy for patients with MVD is largely unknown. Methods and results: Three year clinical outcome of ARTS I patients randomised to PCI with bare metal stent (BMS) (n= 600) or CABG (n= 605), and matched patients treated by PCI with sirolimus-eluting stents (SES) in ARTS II (n= 607) were reviewed according to four age quartiles. Endpoints were measured in terms of major adverse cardiac and cerebrovascular events MACCE) during hospital stay and up to three years. The frequency of female, diabetes, hypertension, peripheral vascular disease, pulmonary disease, as well as lesion complexity increased with age. At three years, MACCE free survival was comparable between patients treated by CABG or SES PCI, regardless of age quartile. The incidence of MACCE was higher among ARTS I BMS treated patients in all but the second age quartile. This was primarily related to a higher need for repeat revascularisation among BMS treated patients. However, age, which emerged as a strong independent predictor of MACCE following CABG (p<0.005), was not predictive of adverse events following PCI. Conversely, diabetes was the strongest independent predictor of MACCE among PCI treated patients (p<0.02), but didn't affect three-year outcomes following CABG. Conclusions: Age seems to influence the CABG outcome in-hospital but not PCI. PCI-SES could offer lower immediate risk in patients with MVD and comparable long-term outcome as CABG especially in older patients. The worst outcome of PCI-BMS group is primarily related to the need for repeat revascularisation. Diabetes is the most important predictor of MACCE following PCI

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Erasmus University Digital Repository

Influence of age on the clinical outcomes of coronary revascularisation for the treatment of patients with multivessel de novo coronary artery lesions: Sirolimus-eluting stent vs. coronary artery bypass surgery and bare metal stent, insight from the multicentre randomised Arterial Revascularisation Therapy Study Part I (ARTS-I) and Part II (ARTS-II)

http://orbi.ulg.ac.be/bitstream/2268/169950/1/Legrand%20ARTS%20age%20EuroInterv..pdf

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Erasmus University Digital Repository

EUR Research Repository