Kontogeorgis, Georgios M.

Various disciplines of chemical engineering, especially thermodynamics and kinetics, play an important role in medicinal research and this has been particularly recognized during the last 10–15 years (von Stockar and van der Wielen, J Biotechnol 59:25, 1997; Prausnitz, Fluid Phase Equilib 53:439, 1989; Prausnitz, Pure Appl Chem 79:1435, 2007; Dey and Prausnitz, Ind Eng Chem Res 50:3, 2011; Prausnitz, J Chem Thermodynamics 35:21, 2003; Tsivintzelis et al. AIChE J 55:756, 2009). It is expected that during the twenty-first century chemical engineering and especially thermodynamics can contribute as significantly to the life sciences development as it has been done with the oil and gas and chemical sectors in the twentieth century. Moreover, it has during the recent years recognized that thermodynamics can help in understanding diseases like human cataract, sickle-cell anemia, Creuzfeldt- Jacob (“mad cow” disease), and Alzheimer’s which are connected to “protein aggregation.” Several articles in the Perspectives section of prominent chemical engineering journals have addressed this issue (Hall, AIChE J 54:1956, 2008; Vekilov, AIChE J 54:2508, 2008). This work reviews recent applications of thermodynamics (and other areas of chemical engineering) first in drug development and then in the understanding of the mechanism of Alzheimer’s and similar diseases

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The role of chemical engineering in medicinal research including Alzheimer’s - DTU Orbit(08/11/2017) The role of chemical engineering in medicinal research including Alzheimer’sVarious disciplines of chemical engineering, especially thermodynamics and kinetics, play an important role in medicinalresearch and this has been particularly recognized during the last 10–15 years (von Stockar and van der Wielen, JBiotechnol 59:25, 1997; Prausnitz, Fluid Phase Equilib 53:439, 1989; Prausnitz, Pure Appl Chem 79:1435, 2007; Dey andPrausnitz, Ind Eng Chem Res 50:3, 2011; Prausnitz, J Chem Thermodynamics 35:21, 2003; Tsivintzelis et al. AIChE J55:756, 2009). It is expected that during the twenty-first century chemical engineering and especially thermodynamics cancontribute as significantly to the life sciences development as it has been done with the oil and gas and chemical sectorsin the twentieth century. Moreover, it has during the recent years recognized that thermodynamics can help inunderstanding diseases like human cataract, sickle-cell anemia, Creuzfeldt- Jacob (“mad cow” disease), and Alzheimer’swhich are connected to “protein aggregation.” Several articles in the Perspectives section of prominent chemicalengineering journals have addressed this issue (Hall, AIChE J 54:1956, 2008; Vekilov, AIChE J 54:2508, 2008). This workreviews recent applications of thermodynamics (and other areas of chemical engineering) first in drug development andthen in the understanding of the mechanism of Alzheimer’s and similar diseases. General informationState: PublishedOrganisations: Center for Energy Resources Engineering, Department of Chemical and Biochemical Engineering, CERE –Center for Energy Ressources EngineeringAuthors: Kontogeorgis, G. M. (Intern)Pages: 57-62Publication date: 2015 Host publication informationTitle of host publication: GeNeDis 2014Volume: 821Publisher: SpringerEditors: Vlamos, P., Alexiou , A.ISBN (Print): 978-3-319-08938-6ISBN (Electronic): 978-3-319-08939-3Chapter: 10 Series: Advances in Experimental Medicine and BiologyISSN: 0065-2598Main Research Area: Technical/natural sciencesDOIs: 10.1007/978-3-319-08939-3_10. Source: FindItSource-ID: 2288386059Publication: Research - peer-review › Book chapter – Annual report year: 2015 

The role of chemical engineering in medicinal research including Alzheimer’s

Georgios M. Kontogeorgis

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