Dau, Torsten

Encina Llamas, Gerard

Epp, Bastian

M. Harte, James

Online Research Database In Technology

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Downloaded from orbit.dtu.dk on: Dec 21, 2017Evaluation of peripheral compression and auditory nerve fiber intensity coding usingAuditory Steady-State Responses (ASSR)Encina Llamas, Gerard; Epp, Bastian; M. Harte, James; Dau, TorstenPublication date:2015Link back to DTU OrbitCitation (APA):Encina Llamas, G., Epp, B., M. Harte, J., & Dau, T. (2015). Evaluation of peripheral compression and auditorynerve fiber intensity coding using Auditory Steady-State Responses (ASSR) [Sound/Visual production (digital)].5th International Symposium on Auditory and Audiological Research, Nyborg, Denmark, 26/08/2015Evaluation of peripheral compression and auditory nerve fiber intensity coding using Auditory Steady-State Responses (ASSR)Gerard Encina Llamas Bastian Epp,James M. Harte,Torsten Dau,1Technical University of DenmarkInteracoustics Research UnitTechnical University of Denmark27th of August, 2015International Symposium on Auditory and Audiological Research  (ISAAR) , Nyborg (Denmark)Evaluation of peripheral compression and auditory nerve fiber intensity coding using Auditory Steady-State Responses (ASSR)Gerard Encina Llamas Bastian Epp,James M. Harte,Torsten Dau,1Technical University of DenmarkInteracoustics Research UnitTechnical University of Denmark27th of August, 2015International Symposium on Auditory and Audiological Research  (ISAAR) , Nyborg (Denmark)Evaluation of peripheral compression and auditory nerve fiber intensity coding using Auditory Steady-State Responses (ASSR)Gerard Encina Llamas Bastian Epp,James M. Harte,Torsten Dau,1Technical University of DenmarkInteracoustics Research UnitTechnical University of Denmark27th of August, 2015International Symposium on Auditory and Audiological Research  (ISAAR) , Nyborg (Denmark)2The need for SUPRA-threshold evaluation2The need for SUPRA-threshold evaluationHumans in clinics:Saunders and Haggard (1989, 1992); Kumar et al. (2007); Hind et al. (2011)5-10% of patients self-report hearing difficulties wh i le showing norma l audiograms2The need for SUPRA-threshold evaluationHumans in clinics: Physiological studies in animals:Saunders and Haggard (1989, 1992); Kumar et al. (2007); Hind et al. (2011)Lobarinas et al. (2013)5-10% of patients self-report hearing difficulties wh i le showing norma l audiogramsN o r m a l b e h a v i o r a l thresholds with 80% loss of IHCs2The need for SUPRA-threshold evaluationHumans in clinics: Physiological studies in animals:Saunders and Haggard (1989, 1992); Kumar et al. (2007); Hind et al. (2011)Lobarinas et al. (2013)Kujawa and Liberman (2009), Lin et al. (2011), Furman et al. (2013)5-10% of patients self-report hearing difficulties wh i le showing norma l audiogramsN o r m a l b e h a v i o r a l thresholds with 80% loss of IHCsAuditory nerve fibers (ANF) deafferentation i s not reflected as permanent threshold elevation3Compression: Animal data3Compression: Animal dataRuggero et al. (1997)3Compression: Animal dataRuggero et al. (1997)4Compression: Auditory Steady-State Responses•The healthy cochlea shows a compressive growth as a function of stimulation level.4Compression: Auditory Steady-State ResponsesRuggero et al. (1997)•The healthy cochlea shows a compressive growth as a function of stimulation level.•ASSR reflect envelope coding.4Compression: Auditory Steady-State Responses1 kHz @ 80 Hz  m = 85%A · sin(2⇡fct) ·1 +m · sin(2⇡fmt)2 •The healthy cochlea shows a compressive growth as a function of stimulation level.•ASSR reflect envelope coding.4Compression: Auditory Steady-State ResponsesFrequency (Hz)EEG spectrumMagnitude (dB)801 kHz @ 80 Hz  m = 85%A · sin(2⇡fct) ·1 +m · sin(2⇡fmt)2 •The healthy cochlea shows a compressive growth as a function of stimulation level.•ASSR reflect envelope coding.•Compression affects to the envelope, hence it should affect to ASSR.4Compression: Auditory Steady-State ResponsesFrequency (Hz)EEG spectrumMagnitude (dB)80Rønne, F.M.  (2012)5Research questionIs it possible to estimate peripheral compression using ASSR?5Research questionNormalhearingHearingimpaired[Cochlea] I/O functionInput level [dB]ASSR magnitude [dB]linear reference (slope 1)6Results: A representative NH subject    (N=13)EEG noise6Results: A representative NH subject    (N=13)6Results: A representative NH subject    (N=13)7Results: A representative HI subject    (N=7)A B C D7Results: A representative HI subject    (N=7)7Results: A representative HI subject    (N=7)7Results: A representative HI subject    (N=7)7Results: A representative HI subject    (N=7)C D7Results: A representative HI subject    (N=7)NH HI7Results: A representative HI subject    (N=7)7Results: A representative HI subject    (N=7)8Intermediate summaryStimulus level [dB SPL]15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-108Intermediate summaryStimulus level [dB SPL]15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-108Intermediate summaryStimulus level [dB SPL]15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-108Intermediate summaryStimulus level [dB SPL]15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-108Intermediate summaryStimulus level [dB SPL]15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-108Intermediate summaryStimulus level [dB SPL]15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-108Intermediate summaryStimulus level [dB SPL]15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-108Intermediate summaryStimulus level [dB SPL]15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-108Intermediate summary9Contribution of SR fibers to deafferentation9Contribution of SR fibers to deafferentationLiberman (1978)Yates (1990)9Contribution of SR fibers to deafferentationLiberman (1978)Yates (1990)9Contribution of SR fibers to deafferentationLiberman (1978)Yates (1990)9Contribution of SR fibers to deafferentation• Furman et al. (2013) showed that ANF “deafferentation” due to noise over-exposure is more selective to medium- and low-SR fibersLiberman (1978)Yates (1990)10Potential explanationStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-1010Potential explanationStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10ASSR magnitude [dB re 1 7V]Full modulation (m = 100%)10Potential explanationStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10ASSR magnitude [dB re 1 7V]Full modulation (m = 100%)ASSR magnitude [dB re 1 7V]Shallow modulation (m = 25%)10Potential explanationStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10ASSR magnitude [dB re 1 7V]Full modulation (m = 100%)ASSR magnitude [dB re 1 7V]Shallow modulation (m = 25%)10Potential explanationStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10ASSR magnitude [dB re 1 7V]Full modulation (m = 100%)ASSR magnitude [dB re 1 7V]Shallow modulation (m = 25%)ASSR magnitude [dB re 1 7V]10Potential explanationStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10ASSR magnitude [dB re 1 7V]Full modulation (m = 100%)ASSR magnitude [dB re 1 7V]Shallow modulation (m = 25%)ASSR magnitude [dB re 1 7V]10Potential explanationStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10ASSR magnitude [dB re 1 7V]Full modulation (m = 100%)ASSR magnitude [dB re 1 7V]Shallow modulation (m = 25%)ASSR magnitude [dB re 1 7V]ASSR magnitude [dB re 1 7V]Shallow modulation - Deafferentation10Potential explanationStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10ASSR magnitude [dB re 1 7V]Full modulation (m = 100%)ASSR magnitude [dB re 1 7V]Shallow modulation (m = 25%)ASSR magnitude [dB re 1 7V]ASSR magnitude [dB re 1 7V]Shallow modulation - DeafferentationASSR magnitude [dB re 1 7V]10Potential explanationStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10ASSR magnitude [dB re 1 7V]Full modulation (m = 100%)ASSR magnitude [dB re 1 7V]Shallow modulation (m = 25%)ASSR magnitude [dB re 1 7V]ASSR magnitude [dB re 1 7V]Shallow modulation - DeafferentationASSR magnitude [dB re 1 7V]10Potential explanationBharadwaj et al. (2014)11Pilot results: Individual NH subjectsStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10Subject: APGASSR m = 100%ASSR m = 85%ASSR m = 50%ASSR m = 25%Linear Ref.11Pilot results: Individual NH subjectsStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10Subject: APGASSR m = 100%ASSR m = 85%ASSR m = 50%ASSR m = 25%Linear Ref.ASSR magnitude [dB re 1 7V]KGS11Pilot results: Individual NH subjectsStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10Subject: APGASSR m = 100%ASSR m = 85%ASSR m = 50%ASSR m = 25%Linear Ref.ASSR magnitude [dB re 1 7V]KGSASSR magnitude [dB re 1 7V]ject: I C11Pilot results: Individual NH subjectsStimulus level [dB SPL]25 30 35 40 45 50 55 60 65 70 75 80 85 90 95ASSR magnitude [dB re 1 7V]-50-40-30-20-10Subject: APGASSR m = 100%ASSR m = 85%ASSR m = 50%ASSR m = 25%Linear Ref.ASSR magnitude [dB re 1 7V]KGSASSR magnitude [dB re 1 7V]ject: I C11Pilot results: Individual NH subjectsBharadwaj et al. (2015)12Pilot results: Individual NH subjects12Pilot results: Individual NH subjects13Next steps13Next steps13Next stepsLow exposure NH13Next stepsLow exposure NH High exposure NH High exposure mild HI13Next stepsLow exposure NH High exposure NH High exposure mild HI•ASSR are already used in the clinics to estimate thresholds objectively•ASSR growth functions are suggested to be used as a tool to assess compression (and loss of compression) at different frequencies simultaneously•We hypothesize that ASSR growth functions at higher stimulation levels using shallow modulations reflect the integrity of ANFs14ConclusionsThank you! Mange tak! Moltes gràcies!15

Evaluation of peripheral compression and auditory nerve fiber intensity coding using Auditory Steady-State Responses (ASSR)

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Evaluation of peripheral compression and auditory nerve fiber intensity coding using Auditory Steady-State Responses (ASSR)

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