David, Helga Susana Moreira

de Andrade, Pere Tavares Sabina

Förster, Jochen

Gunnarsson, Nina Katarina

Mouillion, Jean-Marie

Møller, Per

Petersen Bjørn, Sara

Plate, Iben

Svensson, Elisabeth Malin

This invention relates to the production of fatty acids and particularly to the production of the polyunsaturated fatty acids (PUFAs) arachidonic acid (ARA) and eicosapentaenoic acid (EPA) in genetically engineered fungal cells, in particular, to metabolically engineered Saccharomyces cerevisiae cells with increased content of ARA and EPA. The invention especially involves improvement of the PUFA content in the host organism through various over-expression of e.g. cytochrome b5 and cytochrome b5 reductase involved in fatty acid desaturation, and heterologous expression of cytochrome b5 and cytochrome b5 reductase and expression of heterologous fatty acid synthases

Online Research Database In Technology

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Metabolically Engineered Fungal Cells With Increased Content Of Polyunsaturated Fatty Acids

http://orbit.dtu.dk/ws/files/103124637/WO2008000277A2.pdf

Metabolically Engineered Fungal Cells With Increased Content Of Polyunsaturated Fatty Acids

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