Jensen, A. C. Ø.

Jensen, Keld A.

Koponen, Ismo K.

Kristensen, Henrik Vejen

Liguori, Biase

Saber, A. T.

Wallin, H.

Online Research Database In Technology

                       General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.  • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal   If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.     Downloaded from orbit.dtu.dk on: Dec 20, 2017NanoSafer vs. 1.1 Nanomaterial risk assessment using first order modelingJensen, Keld A.; Saber, A. T.; Kristensen, Henrik Vejen ; Liguori, Biase; Jensen, A. C. Ø.; Koponen, IsmoK.; Wallin, H.Publication date:2014Document VersionPublisher's PDF, also known as Version of recordLink back to DTU OrbitCitation (APA):Jensen, K. A., Saber, A. T., Kristensen, H. V., Liguori, B., Jensen, A. C. Ø., Koponen, I. K., & Wallin, H. (2014).NanoSafer vs. 1.1 Nanomaterial risk assessment using first order modeling. Poster session presented at TopicalScientific Workshop on Regulatory Challenges in Risk Assessment of Nanomaterials, Helsinki, Finland.hwww.nanosikkerhed.nuttp://nanosafer.i-bar.dk/NanoSafer vs. 1.1 Nanomaterial risk assessment using first order modelingKA Jensen*, AT Saber*, HV Kristensen^, ACØ Jensen*, IK Koponen*, and H Wallin** National Research Centre fpr the Working Environment. Copenhagen, DENMARK^Danish Technologicval Institute, Høje Taastrup, DENMARK# Technological University of Denmark, Kongens Lyngby, DENMARKB Liguori*#,Topical Scientific Workshop on Regulatory Challenges in Risk Assessment of Nanomaterials.Helsinki, 23-24 October 2014. Topic: Challenges in regulatory risk assessment of nanomaterials1. NanoSafer is an online control banding and risk managementtool for Manufactured Nanomaterials (MNM). Hazard assessment andcase-specific exposure potentials are currently combined into anintegrated assessment of risk levels expressed in control bands withassociated risk management recommendations and e-learning. The toolis currently intended for SME’s. Further developments aims at moreadvanced applicability, including administrative and regulatory use.2. Input data are typically available from the producers' technicalinformation sheets. The hazard data are given in the SDS for the closestanalogue bulk material for which the requested occupational exposurelimit (OEL) is given as well. The emission potential is either given by aconstant release rate or the dustiness level determined using theEN15051 rotating drum or similar.CNFQNFEiQFF,inQFF,outV1,inV1,outCFFCFF = (NFNF->FF - NFFF->NF + FFresidual) / VFFCNF = (Ei + NFFF->NF - NFNF->FF + NFresidual) / VNF4. Exposure Estimation is made using a two-box near-field (NF)and far-field (FF) source-to-recepter modelling assuming instant mixing.The emission potential is a constant emission rate (E , mg/min) or thepowder dustiness levels (E mg/kg) multiplied with a default activityenergy factor (H ) and the mass-flow (dM/dt) using either the total mass inthe work cycle or the amount added in each transfer (e.g., bag) if thetransfer takes longer than 1 minute. Powder dispersion and transferbetween the NF and FF are calculated considering convection ( ) andventilation rates (Q) between the NF and FF compartments, the generalFF ventilation rate, and the volumes (V) of the NF and FF compartments.io,ik“nanorelevance”NM with lowsolubility (So < 1 g/L)Is the NM a HARN(a < 3 µm Ù c > 5 µm Ùc/a > 3)traditional riskassessment is suggestedHtot = 1.00Hcoat = 0.45yesnoyesyesyesnoAre there any R-phrasesfor the analogue bulk materialHOEL = 0.20noyesIs the OEL for the analoguebulk material < 1 mg/m3?Is the NM surface modifiedwith an inorganicand/or organic compound?nonoCalculate HtotHOEL = 0.26Calculate accumulatedHR from R-values3. Hazard Evaluation is based on the physicochemicalproperties of the MN (water solubility, aspect ratio, presence of coatings),the occupational exposure limit (OEL) of thenearest bulk analogue compound.risk sentences of the nearest bulk analogue compound deemed relevantfor the respiratory tract and( )( )Õå <= -×= ij jni icarc RRH 11 ( )( )Õå -×= <= jijni itot HHH 115. Scaling is made to enable assessment of the risk level associatedwith the specific NM and work situation. The hazard scale for a NM isgiven by calculated under bullet 2 and take values between 0.2 and1. The exposure potential is scaled by normalizing the 15 min ( )and daily ( ) average exposure level ( ) calculated from firstorder modelling (bullet 4) with a theoretical NM occupational exposurelimit ( ).HEXPEXP EXPOELtotAcute8-hour inano OEL(SSA) f(SSA/ )OELnanonano.is a first order approximation based on a volumespecific surface area paradigme (i.e. toxicity ). A VSSA of30, corresponding to a 200 nm spherical particle with unit density, is usedas the bulk reference. The exposure band take values between 0 and ,where 1 corresponds toµ d¥6. Control Banding and Risk Managemt. Four differentcontrol banding charts with indivdual assessment of the hazard potentialand the potential to exceed acute and 8-hour in the NF and FF,respectively. The control band charts have 5 risk levels (RL), ranging fromRL1 with low hazard and low exposure potential to RL5 with high hazardand or moderate to very high exposure potential. Each RL is associatedwith brief standard guidance on risk management and furtherinformation and advise on risk management is available as up-linked e-learning tools, pamphlets, and a background report..OELnanoAir-exchange in the near-field (QNF)QNF = QFF x (VNF/VFF)+ kCNFQNFSourceEmission rate:Ei = Econstant or Eo x Hi x dM/dtnanonano SSAOELOEL d130 ××=nanoAcuteAcute OELCEXP×=2 nanohourhour OELCEXP -- = 88ToxicityExposure .0.76-1.00 0.51-0.75 0.25-0.50 0.00-0.25>1.00 RL5 RL5 RL5 RL50.51-1.00 RL5 RL5 RL4 RL40.26-0.50 RL5 RL4 RL4 RL30.11-0.25 RL4 RL4 RL3 RL2< 0.11 RL4 RL3 RL2 RL1Material identifyersMaterial nameCAS numberEINICS numberMaterial informationIs the material labeled with a nano-specific word or term?Is the material coated or surface modifiedDimensions of theprimary particles [a£b£c]Specific density of the nanomaterial [d]Solubility of the nanomaterial [So]The specific surface area of the nanomaterial [SA]Powder dustiness [Eo]Safety dataOEL for the comparable coventional material [OEL]Risk sentences [Ri]Desciption of the work process and contextural informationEmission rate if constant source [Econstant]Activity handling energy factor [Hi]Total mass of material handled in each work cycle [M]Duration of the work cycle [tc]Pause between work cycles [tp]Number of work cycles per day [n]Amount of nanomaterial handled in each transfer [m]Time required to add each transfer (spoon, bag, big-bag etc) [tt]Volume of the work room (width, length, height) [V]General Far-field air exchange rate [QFF]Control Band Scaling

NanoSafer vs. 1.1 Nanomaterial risk assessment using first order modeling

http://orbit.dtu.dk/ws/files/101857755/Jensen_et_al_NanoSafer.pdf

NanoSafer vs. 1.1 Nanomaterial risk assessment using first order modeling

Abstract

Similar works

Full text

Available Versions

Online Research Database In Technology