The diuretic and potassium- and magnesium-conserving action of a single dose of frusemide/triamterene, F+TRI (40 mg/50 mg), and hydrochlorothiazide/amiloride, HCT+AMI (50 mg/5 mg), fixed combination preparations were compared in ten healthy adults in a randomised double-blind placebo-controlled study. Urinary volume during 24 hours was significantly higher after HCT+AMI ingestion than after F+TRI. The urine and sodium excretions caused by HCT+AMI lasted markedly longer and were smoother than the short and somewhat unpleasant effects of F+ TRI. HCT+AMI also spared potassium and magnesium relatively more effectively than F + TRI. </jats:p
