IAB-90-0BD0-315000 AM 298,0 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

A Pellicer

Adelina Pellicer

CWJ Granger

D Kwiatkowski

D Osborn

DA Dickey

DA Osborn

E Häggendahl

Fernando Cabañas

FY Wong

G Schwarz

H Akaike

J Riera

Joan Riera

José Javier Serrano

JS Soul

LA Baccalá

M Kluckow

MC Bravo

NA Lassen

Rosario Madero

Bundesministerium fuer Umwelt-, Naturschutz und Reaktorsicherheit, Bonn (Germany)

OpenGrey Repository

Investitionshilfen im Umweltschutz  ein Ueberblick mit Gesetzes-, Verordnungs- und Richtliniensammlung fuer die Unternehmen aus Industrie, Handwerk und Kreditwirtschaft sowie fuer die Freien Berufe

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Pediatric Research

New developments in cerebral blood flow autoregulation analysis in preterm infants: a mechanistic approach

Background:

Impaired autoregulation capacity implies that changes in cerebral perfusion follow changes in blood pressure; however, no analytical method has explored such a signal causality relationship in infants. We sought to develop a method to assess cerebral autoregulation from a mechanistic point of view and explored the predictive capacity of the method to classify infants at risk for adverse outcomes.



Methods:

The partial directed coherence (PDC) method, which considers synchronicity and directionality of signal dependence across frequencies, was used to analyze the relationship between spontaneous changes in mean arterial pressure (MAP) and the cerebral tissue oxygenation index (TOI). PDCMAP>>TOI indicated that changes in TOI were induced by MAP changes, and PDCTOI>>MAP indicated the opposite.



Results:

The PDCMAP>>TOI and PDCTOI>>MAP values differed. PDCMAP>>TOI adjusted by gestational age predicted low superior vena cava flow (≤41 ml/kg per min), with an area under the receiver operating characteristic curve of 0.72 (95% CI: 0.63–0.81; P >MAP did not. The adjusted pPDCMAP>>TOI (the average value per patient) predicted severe intracranial hemorrhage and mortality.



Conclusion:

PDCMAP>>TOI allows for a noninvasive physiological interpretation of the pressure autoregulation process in neonates. PDCMAP>>TOI is a good classifier for infants at risk of brain hypoperfusion and adverse outcomes

Riera Salís, José Manuel

Cabañas, Fernando

Serrano Olmedo, José Javier

Madero, Rosario

Pellicer, Adelina

Archivo Digital UPM

Riera Salis, Jose Manuel

Serrano Olmedo, Jose Javier

Servicio de Coordinación de Bibliotecas de la Universidad Politécnica de Madrid

http://oa.upm.es/41221/1/INVE_MEM_2015_228092.pdf

Investitionshilfen im Umweltschutz ein Ueberblick mit Gesetzes-, Verordnungs- und Richtliniensammlung fuer die Unternehmen aus Industrie, Handwerk und Kreditwirtschaft sowie fuer die Freien Berufe

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Crossref

Archivo Digital UPM

Servicio de Coordinación de Bibliotecas de la Universidad Politécnica de Madrid