Magnetic resonance imaging technique known as DWI (diffusion-weighted
imaging) allows measurement of water diffusivity on a pixel basis for
evaluating pathology throughout the body and is now routinely incorporated into
many body MRI protocols, mainly in oncology. Indeed water molecules motion
reflects the interactions with other molecules, membranes, cells, and in
general the interactions with the environment. Microstructural changes as e.g.
cellular organization and/or integrity then affect the motion of water
molecules, and consequently alter the water diffusion properties measured by
DWI. Then DWI technique can be used to extract information about tissue
organization at the cellular level indirectly from water motion. In general the
signal intensity in DWI can be quantified by using a parameter known as ADC
(Apparent Diffusion Coefficient) emphasizing that it is not the real diffusion
coefficient, which is a measure of the average water molecular motion. In the
simplest models, the distribu- tion of a water molecule diffusing in a certain
period of time is considered to have a Gaussian form with its width
proportional to the ADC. However, water in biological structures often displays
non-Gaussian diffusion behavior, consequently the DWI signal shows a more
complex behavior that need to be modeled following different approaches. In
this work we explore the possibility to quantify the degree to which water
diffusion in biologic tissues is non-Gaussian introducing the AKC parameter
(Apparent Kurtosis Coefficient). In this work we have realized DWI non-Gaussian
diffusion maps to be used in the clinical routine along with standard ADC maps,
giving to the radiologist another tool to explore how much structure inside a
voxel is organized. In particular in this work some prostate DWI examples have
been analyzed and will be shown
