ENHANCEMENT OF PIROXICAM INTRINSIC DISSOLUTION RATE WITH SOLID DISPERSION SYSTEM USING BETA CYCLODEXTRIN

Abstract

Objective: This research was aimed to increase the intrinsic dissolution rate (IDR) of piroxicam with solid dispersion system of piroxicam-betacyclodextrin (SDSPB). This system can overcome the dissolution problem of piroxicam. Method: Determination of piroxicam IDR was performed using intrinsic dissolution tester in 100 rpm speed of stir. Free CO2 water was used as solvent. Piroxicam concentration in was measured using spectrophometer. The piroxicam IDR of SDSPB which was prepared using solvent method with freeze drying was compared with control (piroxicam alone). Then the interaction of piroxicam with betacyclodextrin was analyzed using IR spectra. Result:The IDR of SDSPB and piroxicam pellet are 1.2247 and 0.244 mgcm-2minute-1 respectively. This enhancement was predicted due to inclusion complex and electrostatic interaction of piroxicam and betacyclodextrin. Conclusion: The SDSPB can enhance six times fold of piroxicam IDR (p�0,05). The researches purposed to formulate SDSPB tablet and to test its bioavailability are needed to confirms this IDR enhancement