After a strict 6 day confinement to bed of elderly and senile subjects the oxygen supply of the subcutaneous cellular tissue was impaired, and the intensity of its tissue respiration was somewhat reduced. The vacat-oxygen of the blood and urine, the coefficient of incomplete oxidation, and the oxygen deficiency in the organism were increased

Ivanov, L. A.

Orlov, P. A.

English

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INASA TEHCNICAL MEMORANDUM
	
NASA TM-75521
EFFECT OF 6-DAY HYPOKINESIA ON OXYGEN 2=ABOLISM
INDICES IN ELDERLY AND SENILE SUBJECTS
U 
L. A. Ivanov and P. A. Orlov
Translation of: "Vliyaniye 6-dnevnoy gipokinezii
na pokazateli kislorodnogo obmena v poznilom i
starcneskom vozraste," 'syulleten asperimental'noy
Biologii i t,editsiny, Vol. 76, No. 7, July 1973,
pp. 35-37
AUG iy78
G
^B^1I9i^
(NASA-TM-75521)	 EFFECT OF 6-DAY IIYPCKINESI' 	 N78-27753
ON OXYGEN METABOLISM INDICES IN ELDERLY PID
SFNILE SUBJECTS (National Aeronautics and
Space Administration) 6 p HC b02/4F A01	 nnclas
CSCL OES G3/52 `5725
NA'T'IONAL AERONAUTICS AND SPACE AIMINISTRATION
WA=GTON, D. C. 20546	 JULY 1978
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STANDARD TITLE PAGE
1. RIPULNo.	 NASA
7
2.	 covo , nmenl A(celaen No. R.c.P.enCe Celolep No.
4.	 Title and 1.61.110
IC:EFFECT OF 6-DAY HYPOKINESIA ON OXYGEN	 TABO-
LISM INDICES IN. ELDERLY AND SENILE SUBJECTS
I S.	 P.port Dote
JULY 1978
P411e1ming O,gon.cot.on Cede
7.	 Auth.,(s)
L. A.	 Ivanov and P. A.	 Orlov
6.	 P.tlorming 0 , 60Meel.on Report No.
10.	 w1.. ► Uno N..
9.	 Pe,la,,••.ng 0 , gon,so t .on Nome end Add,...
SCITRAA
Bo\ 5456
Santa Barbara,	 CA 93108
11.	 cont,ect ., C.ont No.
-
13.	 Type of R.pe,t ..d P.t.od Co.ere,1
Translation
12.	 Sponso,.np Agency Nom. and Aee,ess
National Aeronautics and Space Ad:unistration
1:ashinston,	 D.C.	 20546
14.	 Spene.„ ng Agency Code
13. Suppl.mentery Notes
Translation of: "Vliyaniye 6-dnevnoy gipokinezii na pokazateli	 r
kislorodnogo obmena v pozhilom i starcheskom vozraste," Byulleten
Eksperimental'noy Biologii i Meditsiny, Vol. 76, No. 7, July 1973,
pp. 35-37.
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10. Absr,act
After a strict 6-day confinemaat to bed of elderly and senile
subjects the oxygen  supply of the subcutaneous cellular tissue was
impaired, and the intensity of its tissue respiration was somewhat re-
duced. The vacat-oxygen of the blood and urine, the coefficient of
incomplete oxidation,- and the oxygen deficiency in the organism were
increased.
ORIGINAL PAGE, JS
( IF p1 N 1R QUALUYI
16. Distribution Statement 	
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Unclassified - Unlimited
19. Security CIossif. (of this t.porl)	 20. Socuntr Cleseil. (of this Fog.)
	
121. No. of Pogeo
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Unclassified
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I	 Is
I	 A
EFFECT OF 6-DAY HYPOKI;ESIA. ON OXYGEN METABOLISM INDICES
IN ELDERLY AND SENILE SUBJECTS
L. A. Ivanov and P. A. Orlov
After a strict 6-day confinement to bed of elderly and 	 zl^*
senile subjects the oxygen supply of the subcutaneous cellular
tissue was impaired, and the intensity of its tissue respiration
was somewhat reduced. The vacat-oxygen of the blood and urine,
the coefficient of incomplete oxidation, and the oxygen deficiency
in the organism iere increased.
Hypokinesia is a significant factor in premature aging L5, 7, 9, 101.
Due to the role of oxygen deficiency in the development of senile shifts
[4, 6, 8] of especial importance is the study of the hypodynaiic effects on
the oxygen metabolism indices and the oxidation-reduction processes in
elderly and senile people.
This work studied the effect of hypokinesia on the oxygen absorption,
its stress in the tissue, and the content of incompletely oxidized products
in the organism of elderly and senile people.
Technique
Oxygen . stress (PO 2) was determined in the subcutaneous cellular tissue
of the left forearm by the polarographic method. The active cathode was an
exposed platinum needle electrode 0.4 mm in diameter, while the comparison
anode--silver chloride electrode superimposed or. the distal third of the right
shin. Measurements were made with a supply of constant voltage 0.7 v to the
*Numbers in the margin indicate pagination in the orginial foreign text.
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electrodes. Graphic recording was made with the help o^ an automatic
electron potentiometer EPP-09YZ through a photocompenaation amplifier F 116/1.
The results were expressed in millimeters of a mercury column by conducting
electrode calibration after each study in physiological solutions with a
certain oxygen pressure.
As functional tests permitting an evaluation of the oxygen supply to the
subcutaneous cellular tissue and the intensity of its oxygen consumption
10-minute oxygen inhalation and pinching of the vessels in the limb for 10
minutes were used. A spirograph SG-lm was employed to measure out and
record the oxygen load. Spirographic study also made it possible to deter-
mine oxygen absorption and its deficiency in the organism L31.
The content of incompletely oxidized products 4-n the blood was determined
according to Roman's method with correction for sugar according to Hagedorn-
Iensen, and with correction for chlorides according to Levinson. The vacat-
oxygen of the urine was determined by the Brin micromethod with correction
for chlorides according to More, and the protein-free nitrogen of the urine--
P yel'dal's semimicromethod.
Twenty-one essentially healthy men were examined of elderly (60 -74) and
senile (75-89) age before and after a strict 6-day confinement to bed.
Results
After a course of strict confinement to bed for elderly and senile people
the increase in P02
 in the subcutaneous cellular tissue during oxygen
inhalation was reduced from 38.2 ± 4.69 to 24.4 ±3.21 mm Hg (D < 0.02), which
reflects the exacerbation of the oxygen supply to the subcutaneous cellular
tissue. There was a certain tendency for the latent period in the reduction
of P0 2
 in the subcutaneous cellular tissue to be lengthened in the transition
from oxygen inhalation to air respiration (41.6 ± 4.24 sec, as compared to
34.4 ± 4.12 sec. before hypokinesia; 0.2 < D < 0.3), as well as in the test
with vessel constriction (11.9 ± 1 .55 sec. as compared to 8.6 ± 0.92 sec.;
II
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2
•^ 17 7 fT ^r	 --i	 y^1	
.,	 . ^r	 •
0.05 < D 6.1).
The indicated parameters reflect the intenst.y of tissue respiration,
and they increase with its reduction '_2 	 The reality of the noted trend
towards reduction in oxygen consumption of the subcutaneous cellular tissue
after hypokinesia is confirmed by the Fact that dc-pite the significant
drop in PO  increase during oxygen inhalation under these conditions, the
length of stabilization of the PO  level during the transition from oxygen
respiration to air respiration essentially was not altered (respectively
483.6 ± 31.92 and 473.2 ± 27.39 sec.). In addition, despite the exacerbation
in the oxygen supply to the subcutaneous cellular tissue, the amount of PO 
in this tissue in the elderly and senile subjects after hypokinesia was
practically preserved at the initial level ( 48.6 ± 2.62 mm Hg).
After the hypokinesia course oxygen absorption in the elderly and senile
subjects did not change (214.2 -!20.12 ml/min with initial 228.9 t 8.54 ml/min).
EFFECT OF HYPOKINESIA ON OXIDATION-REDUCTION PROCESSES INDICES
IN ELDERLY AND SENILE SUBJECTS (M t m)
Index	 i Before	 After	 iD
h pokinesiah^okinesia
Vacat-oxygen of diurnal urine (ia g)
	 9.08 ± 0.91
	 11.5 ± 0.52< 0.05
Coefficient of incomplete oxidation
	 1.14 = 0.034	 1.36 ± 0.059 < 0.001
Vacat-oxygen of blood (in mg%)
	 233 ± 9.08	 270 ± 9.71	 0.01
In individuals of elderly and senile age after a 6-day bed oonfinement
the level of vacat-oxygen increased in the blood and diurnal urine, and
the coefficient of incomplete oxidation was augmented (see the table). The
reliable increase in concentration of incompletely oxidized products in
the blood and urine reflects the exacerbation in the oxidation-reduction
processes under conditions of hypokinesia, which results in a less complete
oxidation of the metabolites. An increase in the coefficient of incomplete
oxidation indicates that the oxidation reactions are less complete.
As is known, excess oxygen absorption from hyperoxic mixtures as
	 !J27
compared to oxygen absorption during air respiration ("oxygen deficit") is
	
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I	 governed by an accumlation of metabolites in the organism whose oxidation
consumes an additional quantity of oxyron [1, 11]. This is why an increaso
In the "oxygen deficit" in the organism that is detected in elderly and
senile people after a 6-day hypokinesia (24.8 ± 3,76% versus 12.2 ± 1 .33 %;
D < 0.003) can be explained by the increase in the level of incompletely
oxidized products detected under such conditions.
References
1. Dembo, A. G., Neaostatochnost' funktsii vneshneCo dyzhaniya ["Deficiency
in the Function of External Respiration"7, Leningrad, 1957.
2. Korkushko, 0. V. and L. A. Ivanov, K.lin, med., No. 12 (1969), p. 54.
3. K ork ushko, 0. V. and L. A. Ivanov, Ficiol.. ..h. SSSR, No. 12 (1970), P. 1813.
4. Mil'man, M. S., in Starost' L"Old A L;a"], Kiev, 1939, p. 41.
5. Mogendovich, M. R., in Dvigatel_'na a aktivnost' i stareniye LN,otor Activity
and Aging, Kiev, 1969, p. 227.
	 — —
6. Sirotinin, N. N., Klin. mod., No. 8 (1960), P. 72.
I
7. Frol'kis, V. V. and I. V. Muraviov, in Fi^icheskaya kul'tura--istoch--nik
dolgoletiLa L"Athletics -- the Source of Longevity" , Yoscow, 1965, p. 24.
8. Chebotarcw, D. F., 0. V. Korkt:ohko, a-nd L. A. Ivanov, in Stareniye i
fiziologich©skive sistem orranizma L"Aging and the Physiological
System of the Organism" , Kiev, 1969, p. 221.
	
'	 9. Kraus, H. and W. Raab, HyU)gkinntic Dise1se, Springfield, 1961.
10. Le Compte, H. Z., AlternstoXsch No. 18 ( 1 965), P. 79.
11. Uhlenbruck, P.,	 Les. exp. P:ed.. No. 74 (1930), p. 1.
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Effect of 6-day hypokinesia on oxygen metabolism indices in elderly and senile subjects

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