Vestibulo-sensory reactions were studied in 135 workers who were in contact with nitroethers, by the method of an experimental caloric test. The response vestibulo-sensory reactions were recorded by means of an electroencephalograph. The changes in the sensory reaction depended on the duration of the workers' contact with toxic agents. A study of illusion reactions by the labyrinth calorization widens diagnostic possibilities in the examination of functional condition of the vestibular analyser considerably

Kapranov, V. Z.

English

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vNASA TECHNICAL MEMORANDUM	 NASA TM-76386
i
(1iASA-TH-76386) CHkfikCTEkISTICS OF 	 N81-20718
YESTIBULOSLNSORY HEACsZONS STUDIED BY
EXPERIMENTAL CALORIC ZEST (National
Aeroaautics and Space Administration) 6 p	 Unclas
HC AJ2/KF A01	 CSCL 06P G5/52 19772
CHARACTERISTICS OF VESTIBULOSENSORY REACTIONS
STUDIED BY EXPERIMENTAL CALORIC TEST
V. Z. Kapranov
Translation of "K Kharakteristike vestibulo-
sensornykh reaktsiy, issleduyemykh metodom
eksperimental'noy kaloricheskoy proby,"
Vestnik otorinolaringologii, No. 1 (Jan-Feb),
1979, pp. 48-49.
NATIONAL AERONAUTICS AND SPACE ADMINISTRATION
WASHINGTON D.C. 20546 	 SEPTEMBER 1980
RE,r'1%`:r^ CT!ON RESTRICTIONS OVERRIDDEN
Zit+LA Sciontific and Technical Iuformation 1'aciiity
t` STANDARD TITLE PAGE
1. Ryett No. L OevotenaM Accession No. k Reelpiont's Cately No.
NASA	 6
t. Tide end Sr►ade S. Rgert Dole
CHARACTERISTICS OF VESTIBULOSENSORY SEPTEMBER	 80
. IotfeuMq Omeeisetien CedeREACTIONS STUDIED BY EXPERIMENTAL CALORI
TEST
7. AV#"G) 4. '«bnnl" Or#"action Rowe No.
V. Z. Kapranov Is. weA unit He.
7. 'etlone'ny OtIonieetien None end Addteee 11. CenMeet M Oteat No.
SCITRAN HASW-3198
IL Typo of Report end ►etiod Co+e"ABox 5456
Santa Barbara, CA 93108 Translation
13. 4"setint Asoncr None and Addtess
National Aeronautics and Space Administration 11. Speneetitte Avoncr Code,
Washington, D.C.	 20546
ls. 
r'	 n1T`sa?J1iori of "K Kharakteristike vest ibulosensornykh reaktsly,
issieduyemykh metodom eksperimental'noy kaloricheskoy proby",
Vestnik otorinolaringologii, No.	 1 (Jan-Feb), 1979, pp.	 48-49
16.	 A► s ►tec
Vestibulo-sensory reactions were studied in 135 workers who
were in contact with nitroethe.rs, by the method of an
experimental caloric	 test.	 The-response vestibulo-sensory
reactions were recorded by means of an electroencephalograph.
The changes in the.sensory reaction depended on the duration
of the workers' contact with tcxic agents. 	 A study of
illusion reactions by the labyrinth calorization widens
diagngstic possibilities in the examination of functional
condition of the vestibular analyser considerably.
17. Key Muds ("64194 by Arthex(a) 11. DielribnNon Siot etent
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CHARACTERISTICS OF VESTIBULOSENSORY REACTIONS
STUDIED BY EXPERIMENTAL CALORIC TEST
V. Z. Kapranov
Extensive experimental and clinical material has been accu- 	 /48*
mulated on the mechanism for the vestibular effects on the develop-
ment of the autonomic complex during stimulation of the labyrinth
(V. I. Voyachek, 1927; A. V. Zhukovich, 1946; K. L. Khilov, 1969;
V. Ye. Busygin and Yu. G. Grigor'yev, 1962; S. S. Markaryan and
R. A. Vartbaronov, 1966; Yu. G. Grigor'yev et al., 1970; and
others).
A number of works in the domestic literature have covered
a study of the sensory reactions in response to adequate stimula-
tion of the labyrinth (N. I. Kostrov, 1957; V. G. Bazarov, 1964;
Yu. G. Grigor'yev et al., 1970; A. Ye. Kurashvili and V. I. Babi-
yak, 1975, and others), however, there is no information on the
effect of caloric stimulation of the labyrinth on the thresholds
of the vestibulosensory reactions.
The purpose of this work is to investigate the duration or the
vestibulosensory reactions in workers of the chemical industry
who are expposed to the effect of nitroesters (nitroglycerin and
its analogs). The duration of the sensory reaction was deter-
mined from the time for the rotation illusion sensation in response
to experimental stimulation of the labyrinth by irrigating the
meatus acusticus externus with 100 ml of water at a temperature
Numbers in margin indicate pagination in original foreign text.
1
of 19°C for 10 s (N. S. Blagoveshchenskaya, 1962). At the moment
the sensation of vertigo appeared the subject pressed a button
installed in chair arm rest, and this signal was noted on the
electroencephalographic tape in the form of a flash-up. At the
end of the rotation sensation the subject again pressed the button
and a second mark was recorded on tape of the self-recorder. The
material was digitally processed on an M-220 computer.
As a result of the study on the duration of illusory
sensation during caloric stimulation of the labyrinth in a group
of practically healthy individuals (control group--30 people) a
considerable variability was noted in this reaction, while the
average duration of the vestibulosensory reaction (M±m) was 47.84±
4.23 s, o±24.33.
The results of a statistical analysis of the illusory reactions
in the workers of the main production groups indicate an in-
crease in their duration in the group of workers with the greatest
production length of service (D<0.001;see table).
Comparison of the indices for the vestibulosensory reactions
in workers of the main production groups with the same indices
in individuals of the control group indicates the change in the
vestibulosensory reactions in the workers who have contact with
nitroesters. A dependence is noted of the change in thresholds
of illusory sensations on the duration of contact with the toxic
substances. Our studies made it possible to hypothesize that the
cause for the disruption in the vestibulosensory reaction. in
workers of the industry we studied is the change as a result of
the general toxic effect of nitroesters on the organism of
the workers, and the functional condition of the cerebral centers
that regulate the sensory reactions.
The study of the vestibular functinns in workers of the
industry we studied revealed a varying degree of important
2
CHANGES IN DURATION OF VESTIBULOSENSORY REACTION DEPENDING ON
4	 LENGTH OF WORK
r
Length of work,	 ears Statistical Index
I
t^ * e r
t
Control 9D	 47,84	
1
4,23 24,93 ^
from 0 to
from 2 to 5 15	 00.46 5.36 18 . 57 LU ]0.05
from 5 to 10 7®39690 4.23 32:26 4.n
Go .0D1over 10 40	 81.02 5.35 32.10 4.85
labyrinth reactions. Thus, in 14 people (9.8X) in the presence
of pronounced vestibulosensory and vestibulo-autonomic reactions
there was a considerable su ppression of the vestibulosomatic
reactions (nystagmus). In 2 workers (1.5X) complete absence of
nystagmus was noted with sharply pronounced autono mic and sensory /49
manifestations. Dissociation of the reflex vestibular reactions
was determined by the disruption in the normal strength correlations
between the amount of the response reaction of the organism and
the strength of the employed stimulus. These paradoxical reactions
reflect the phase condition of the vestibular analyzer and indicate
the decompensated stage of affection of the vestibular analyzer
in the workers who contacted nitroesters (N. S. Blagoveshchenskaya,
1978).
The vestibulosensory reactions are constant components of
the reflex reaction in response to the caloric stimulus of the
labyrinth. A study of the illusory reactions by exaerimental
caloric test permits a more complete assessment of the functioning
of the vestibular analyzer. The given test can be recommended
to assess the condition of the vestibulosensory system in a study
of the vestibular analyzer in the clinical practice of occupational
diseases.
geferences
Bazarov, V. G. Vliyanive nekotorykh ekstrarazdrazhateley na
3
ra hennost' vestibulo -ve etativnykh r^eak^*_siy ["Effect of
Certain Extrastimuli on the ronouncedaI^ ture of Vestbilo-
Autonomic Reactions"], Author ' s abstract of cand, diss., Lenin-
grad, 1964.
Blagovesh chenskaya, N. S. ToRicheskoye znacheniye narusheniv slukha
vestibulyarn2l funktsii, obonyaniya i vkusa pri por^azheni akkh
olovnogo_ mozga [ opFcal Importance of DIso ers in Near ng,
Vestibuiar-fiction, Sense of Smell and Taste in Affections
of the Brain"], Moscow, 1962.
Blagoveshchenskaya, N. S. Vestn. otorinolar., No. 1 (1978), p. 72-
78.
Busygin, V. Ye.; and Grigor'yev, Yu. G. Byull. eks er. biol., No. 7
(1962), p. 102-104.
Voyachek, V. I. Zh. ushn., nos. i porl. bol., No. 3-4 (1927), p. 121-
Grigor'yev, Yu. G.; Farber, Yu. V.; and Volokhova, N. A. Vestibu-
Ivarnyye reaktsii ["Vestibular Reactions"], Moscow, 1970.
Zhukovich, A. V. Trudy!  vvo, yen-m_orsk. med. akad. ["Proc. of Naval
Med. Acad."]Vol. 6. -1-94-6 , p. 19Y-MO.
Kostrov, N. I. Y analizu diagnosticheskop primeneniya vestibul-
yarnvkh prob v_ klinike i eksverimente_["Analysis of Diagnostic
Application of Vestibular Tests in the Clinic and Experiment"]
Author's abstract of cand. diss., Leningrad, 1957.
Kurashvili, A. Ye.; and Babiyak, V. I. Fiziolo icheski "funktsii
Yestibulyarnoy.sistei my["Physiological Function_ oT Vesti^-
lar System"], Leningrad, 1975.
Markarvan, S. S.; and Vartbaronov, R. A. IZy, AN SSSR. Ser. biol.,
No. 2 (1966), P. 221-229.
Khilov, K. L. Funk^ organa ravnovesiya i bolezn' peredvizheniya
["Function of the Organ of Equilibrium and Motion Sickness"]
Leningrad, 1969.
4


Characteristics of vestibulosensory reactions studied by experimental caloric test

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