Responses to LBNP in men with varying profiles of strength and aerobic capacity: Implications for flight crews

Abstract

Hemodynamic and hormonal responses to lower-body negative pressure (LBNP) were examined in 24 healthy men to test the hypothesis that responsiveness of reflex control of blood pressure during orthostatic stress is associated with strength and/or aerobic capacity. Subjects underwent treadmill tests to determine peak oxygen uptake (peak VO2) and isokinetic dynamo meter tests to determine leg strength. Based on predetermined criteria, the subjects were classified into one of four fitness profiles of six subjects each matched for age, height, and weight: (1) low strength/low aerobic fitness; (2) low strength/high aerobic fitness; (3) high strength/low aerobic fitness; and (4) high strength/high aerobic fitness. Following 90 min of 6 degree head-down tilt (HDT), each subject underwent graded LBNP through -50 mmHg or presyncope, with maximal duration 15 min. All groups exhibited typical hemodynamic, hormonal, and fluid shift responses during LBNP, with no intergroup differences except for catecholamines. Seven subjects, distributed among the four fitness profiles, became presyncopal. Subjects who showed greatest reduction in mean arterial pressure (MAP) during LBNP had greater elevations in vasopressin and lesser increases in heart rate and peripheral resistance. Peak VO2 nor leg strength were correlated with fall in MAP or with syncopal episodes. We conclude that neither aerobic nor strength fitness characteristics are good predictors of responses to LBNP stress