Brown, Daniel F.

Griffin, DeVon W.

McKay, Terri L.

McQuillen, John B.

Zoldak, John T.

NASA Technical Reports Server

Intravenous Fluid Generation (IVGEN)
for Exploration Missions 
Terri L. McKay1, John B. McQuillen1, Daniel F. 
Brown2, John T. Zoldak2, DeVon W. Griffin1 
National Aeronautics and Space Administration 
www.nasa.gov  
1NASA Glenn Research Center 
Cleveland, OH 
NASA Human Research Program Investigators’ Workshop, 
February 14, 2012 
2ZIN Technologies, Inc. 
Middleburg Heights, OH 
https://ntrs.nasa.gov/search.jsp?R=20150010358 2019-08-31T08:03:58+00:00Z
National Aeronautics and Space Administration 
Overview 
•  IVGEN Objectives 
•  Project History 
•  ISS Demonstration Hardware Overview 
•  Exploration Mission Hardware Concept 
•  Post-flight hardware analysis 
•  Lifetime testing 
2 
National Aeronautics and Space Administration 
IVGEN Objectives 
•  Design a system to produce IV fluids including: 
•  Compact water purification 
•  Integrated reduced gravity pharmaceutical mixing 
•  Product meeting USP standards 
•  Minimize volume and mass for the required production 
rate 
•  Filter capacity should be easily re-scalable to meet 
exploration requirements and constraints 
•  Submit IVGEN to a Technology Demonstration aboard 
the ISS 
3 
National Aeronautics and Space Administration 
IVGEN Project History 
•  Laboratory Study for Microgravity Mixing 
•  Trade Studies for Technologies to Generate 
Medical Grade Water in Microgravity 
•  Laboratory Study for Technologies to 
Generate Medical Grade Water in Microgravity 
•  Flight Experiment (May 2010) and Flight Data 
Analysis 
•  Exploration Mission Design Recommendation 
4 
National Aeronautics and Space Administration 
ISS Demonstration Hardware Overview 
Power Supply DACU 
Accumulator Purifier Mixer 
MSG •  Operate in the Microgravity 
Science Glovebox (MSG) on 
ISS 
•  Data Acquisition and Control 
Unit (DACU) handles data 
flow and storage 
•  Accumulator drives water 
flow through the system 
•  Purifier filters water and 
contains diagnostic 
instruments 
•  Mixer combines purified 
water with the sodium 
chloride 
5 
National Aeronautics and Space Administration 
ISS Demonstration Hardware Overview 
Accumulator 
6 
National Aeronautics and Space Administration 
ISS Demonstration Hardware Overview 
Purifier 
7 
National Aeronautics and Space Administration 
ISS Demonstration Hardware Overview 
Mixer Collection 
Bag 
Mixing 
Bag 
8 
National Aeronautics and Space Administration 
IVGEN Exploration Design 
GN2 Hose 
Hand Pump 
(optional) 
Accumulator Purifier 
Mixer Mixing Bag 
IV Bag 
9 
National Aeronautics and Space Administration 
Post Flight Hardware Analysis 
•  Visual inspection for damage, 
contamination, and/or deterioration 
•  Assess system’s ability after sitting unused 
for two years 
•  Measure hold-up volume of system 
•  Test remaining Saline Bags 
10 
National Aeronautics and Space Administration 
Ongoing Lifetime Testing 
•  Packaging material 
•  Packaging technique 
•  Cartridge material 
•  Resin volume 
11 
DI Resin 
DI Resin Cartridge 
National Aeronautics and Space Administration Your Title Here 12 


Intravenous Fluid Generation (IVGEN) for Exploration Missions

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