We investigate two-photon quantum interference in an opaque scattering medium
that intrinsically supports 106 transmission channels. By adaptive spatial
phase-modulation of the incident wavefronts, the photons are directed at
targeted speckle spots or output channels. From 103 experimentally available
coupled channels, we select two channels and enhance their transmission, to
realize the equivalent of a fully programmable 2×2 beam splitter. By
sending pairs of single photons from a parametric down-conversion source
through the opaque scattering medium, we observe two-photon quantum
interference. The programmed beam splitter need not fulfill energy conservation
over the two selected output channels and hence could be non-unitary.
Consequently, we have the freedom to tune the quantum interference from
bunching (Hong-Ou-Mandel-like) to antibunching. Our results establish opaque
scattering media as a platform for high-dimensional quantum interference that
is notably relevant for boson sampling and physical-key-based authentication