SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : 26165 F, issue : a.1997 n.48 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Das, Gaurav

Felsenberg, Johannes

Huetteroth, Wolf

Owald, David

Perisse, Emmanuel

Talbot, Clifford B.

Waddell, Scott

PubMed

SummaryDuring olfactory learning in fruit flies, dopaminergic neurons assign value to odor representations in the mushroom body Kenyon cells. Here we identify a class of downstream glutamatergic mushroom body output neurons (MBONs) called M4/6, or MBON-β2β′2a, MBON-β′2mp, and MBON-γ5β′2a, whose dendritic fields overlap with dopaminergic neuron projections in the tips of the β, β′, and γ lobes. This anatomy and their odor tuning suggests that M4/6 neurons pool odor-driven Kenyon cell synaptic outputs. Like that of mushroom body neurons, M4/6 output is required for expression of appetitive and aversive memory performance. Moreover, appetitive and aversive olfactory conditioning bidirectionally alters the relative odor-drive of M4β′ neurons (MBON-β′2mp). Direct block of M4/6 neurons in naive flies mimics appetitive conditioning, being sufficient to convert odor-driven avoidance into approach, while optogenetically activating these neurons induces avoidance behavior. We therefore propose that drive to the M4/6 neurons reflects odor-directed behavioral choice

Elsevier - Publisher Connector 

Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila 

Galtier, J.

Klein, P.

Electricite de France (EDF), 91 - Clamart (France). Direction des Etudes et Recherches (DER)

Electricite de France (France), 92 - Clamart (France). Dept. Mecanique et Modeles Numeriques

OpenGrey Repository

Un preprocesseur parallele pour le logiciel de mecanique des fluides HPCN3S

During olfactory learning in fruit flies, dopaminergic neurons assign value to odor representations in the mushroom body Kenyon cells. Here we identify a class of downstream glutamatergic mushroom body output neurons (MBONs) called M4/6, or MBON-β2β'2a, MBON-β'2mp, and MBON-γ5β'2a, whose dendritic fields overlap with dopaminergic neuron projections in the tips of the β, β', and γ lobes. This anatomy and their odor tuning suggests that M4/6 neurons pool odor-driven Kenyon cell synaptic outputs. Like that of mushroom body neurons, M4/6 output is required for expression of appetitive and aversive memory performance. Moreover, appetitive and aversive olfactory conditioning bidirectionally alters the relative odor-drive of M4β' neurons (MBON-β'2mp). Direct block of M4/6 neurons in naive flies mimics appetitive conditioning, being sufficient to convert odor-driven avoidance into approach, while optogenetically activating these neurons induces avoidance behavior. We therefore propose that drive to the M4/6 neurons reflects odor-directed behavioral choice

Talbot, Clifford

Oxford University Research Archive

Activity of defined mushroom body output neurons underlies learned olfactory behavior in Drosophila

KOPS - The Institutional Repository of the University of Konstanz

Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila

ORA - Oxford University Research Archive

Owald, D

Felsenberg, J

Talbot, CB

Das, G

Perisse, E

Huetteroth, W

Waddell, S

Oxford University Research Archive (ORA)

Neuron

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Un preprocesseur parallele pour le logiciel de mecanique des fluides HPCN3S

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Oxford University Research Archive

KOPS - The Institutional Repository of the University of Konstanz

Elsevier - Publisher Connector

ORA - Oxford University Research Archive

Oxford University Research Archive (ORA)