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The approximate coordinate exchange algorithm for Bayesian optimal design of experiments

Abstract

Optimal Bayesian experimental design typically involves maximising the expectation, with respect to the joint distribution of parameters and responses, of some appropriately chosen utility function. This objective function is usually not available in closed form and the design space can be of high dimensionality. The approximate coordinate exchange algorithm is proposed for this maximisation problem where a Gaussian process emulator is used to approximate the objective function. The algorithm can be used for arbitrary utility functions meaning we can consider fully Bayesian optimal design. It can also be used for those utility functions that result in pseudo-Bayesian designs such as the popular Bayesian D-optimality. The algorithm is demonstrated on a range of examples

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