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A Gallagher

A Siddon

Adam J. Bell

Alice Gallagher

Annette Lake

B Geraudie

BJ Hindson

CB Hall

D Ablashi

D Boutolleau

DA Clark

DM Zerr

EC Leibovitch

Eleanor V. Kane

EP Nacheva

ET Chang

EV Willett

Eve Roman

FE Alexander

G Torelli

HN Leong

JH Arbuckle

KN Ward

M Bates

M Daibata

M Luppi

NP Tavakoli

P Hubacek

RH Sedlak

Riccardo Dolcetti

Ruth F. Jarrett

S Dewhurst

SE Artandi

SW Aberle

Timothy Mottram

Tracy Lightfoot

V Strenger

Y Huang

PLoS ONE

PubMed

<div><p>A unique feature of both human herpesvirus 6A and B (HHV-6A and B) among human herpesviruses is their ability to integrate into chromosomal telomeres. In some individuals integrated viral genomes are present in the germ-line and result in the vertical transmission of HHV-6; however, little is known about the disease associations of germ-line transmitted, chromosomally integrated HHV-6 (ciHHV-6). Recent publications suggest that HHV-6 is associated with classical Hodgkin lymphoma (cHL). Here we examine the prevalence of ciHHV-6 in 936 cases of cHL and 563 controls by screening with a duplex TaqMan assay and confirming with droplet digital PCR. ciHHV-6 was detected in 10/563 (1.8%) controls and in all but one individual the virus was HHV-6B. Amongst cases 16/936 (1.7%) harboured ciHHV-6, thus demonstrating no association between ciHHV-6 and risk of cHL.</p></div

Adam J. Bell (657385)

Alice Gallagher (657386)

Timothy Mottram (657387)

Annette Lake (657388)

Eleanor V. Kane (657389)

Tracy Lightfoot (588162)

Eve Roman (657390)

Ruth F. Jarrett (657391)

The Francis Crick Institute

Germ-Line Transmitted, Chromosomally Integrated HHV-6 and Classical Hodgkin Lymphoma

Crossref

A unique feature of both human herpesvirus 6A and B (HHV-6A and B) among human herpesviruses is their ability to integrate into chromosomal telomeres. In some individuals integrated viral genomes are present in the germ-line and result in the vertical transmission of HHV-6; however, little is known about the disease associations of germ-line transmitted, chromosomally integrated HHV-6 (ciHHV-6). Recent publications suggest that HHV-6 is associated with classical Hodgkin lymphoma (cHL). Here we examine the prevalence of ciHHV-6 in 936 cases of cHL and 563 controls by screening with a duplex TaqMan assay and confirming with droplet digital PCR. ciHHV-6 was detected in 10/563 (1.8%) controls and in all but one individual the virus was HHV-6B. Amongst cases 16/936 (1.7%) harboured ciHHV-6, thus demonstrating no association between ciHHV-6 and risk of cHL

Adam J Bell

Eleanor V Kane

Ruth F Jarrett

Directory of Open Access Journals

Germ-line transmitted, chromosomally integrated HHV-6 and classical Hodgkin lymphoma.

Bell, Adam J.

Gallagher, Alice

Mottram, Timothy

Lake, Annette

Kane, Eleanor V.

Lightfoot, Tracy

Roman, Eve

Jarrett, Ruth F.

Enlighten

English

Germ-line transmitted, chromosomally integrated hhv-6 and classical Hodgkin lymphoma

Enlighten: Publications

http://dx.plos.org/10.1371/journal.pone.0112642