Immunization of mice with killed organisms of Corynebacterium renale did not prevent the ascending of organisms of C. renale from the urinary bladder into the kidneys, despite the fact that the antibodies against the organisms were produced in mice. The rate of the ascending of organisms into the kidneys in athymic nude (nu/nu) mice and their heterozygous littermates (nu/+) with C. renale inoculated into the urinary bladder did not significantly differ. BCG-pretreatment did not significantly influence the ascending of C. renale from the urinary bladder into the kidneys. The results may indicate that the ascending of C. renale from the urinary bladder into the kidneys is not seriously affected by systemic humoral and cell-mediated immunity
