It is urgent to find alternative agents due to increasing failure rate of Helicobacter pylori (H. pylori) eradication. The study surveyed the long-term effect of silver nanoparticles (AgNP) on H. pylori based on Mongolian gerbil's model

Chang, Lin-Li

Chen, Yen-Hsu

Chin, Chieh

Kuo, Chao-Hung

Kuo, Fu-Chen

Liu, Chung-Jung

Lu, Chien-Yu

Su, Hong-Lin

Weng, Bi-Chuang

Wu, Deng-Chyang

Yang, Yuan-Chieh

BioMed Research International

PubMed

Background. It is urgent to find alternative agents due to increasing failure rate of Helicobacter pylori (H. pylori) eradication. The study surveyed the long-term effect of silver nanoparticles (AgNP) on H. pylori based on Mongolian gerbil’s model. Materials and Methods. Fifty gerbils were randomly allocated to six groups (A–F). Group (Gr) A: the gerbils were fed with broth; Gr B and D: the gerbils were fed with AgNP/clay complex (0.1% of weight); Gr C and E: the gerbils were fed with AgNP/clay complex(1% of weight); and Gr D, E, and F: the gerbils were inoculated with H. pylori. At the 20th experimental week, the gerbils were sacrificed. Histology was evaluated according to the classification of the Sydney system. P<0.05 was considered to be statistically significant. Results. The AgNP/clay has more obvious inhibitory effect on H. pylori in vitro. There was a trend of higher concentrations of AgNP with stronger inhibitory effect on H. pylori growth (P=0.071). There were no significant differences of inflammation among groups D, E, and F (P=0.688).Conclusion. AgNP/clay would be a potential and safe agent for inhibiting H. pylori. It should be helpful for eradication of H. pylori infection

Chao-Hung Kuo

Chien-Yu Lu

Yuan-Chieh Yang

Chieh Chin

Bi-Chuang Weng

Chung-Jung Liu

Yen-Hsu Chen

Lin-Li Chang

Fu-Chen Kuo

Deng-Chyang Wu

Hong-Lin Su

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Does Long-Term Use of Silver Nanoparticles Have Persistent Inhibitory Effect on H. pylori Based on Mongolian Gerbil’s Model?

National Chung Hsing University Institutional Repository

https://creativecommons.org/licenses/by/3.0/

Does Long-Term Use of Silver Nanoparticles Have Persistent Inhibitory Effect on H. pylori Based on Mongolian Gerbil’s Model?

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National Chung Hsing University Institutional Repository