用氯胺T碘标技术标记抗人肝癌单克隆抗体JH107（MCAbJH107），观测其在载人肝癌bEl7402裸鼠模型上的分布显像情况，氯胺T碘标法标记率50%。每鼠腹腔注射200CI131Ⅰ-MCAbJH107，放射性物质第24H开始在肿瘤部位浓聚、逐步加强，96H达高峰，肿瘤组织较清楚显像并维持至148H；同时周围组织放射性本底逐步减弱、消失。对照组131Ⅰ-nIgg呈全身均匀分布。无明显放射性物质浓聚及清楚显像。在48H和96H，131Ⅰ-MCAbJH107在12种正常组织（脑除外）的T/nT均值分别为3.38和6.26，而131Ⅰ-nIgg的T/nT均值均低于1.0。he monoclonal antibody JH107,(McAbJH107)against human liver cancerwas labelled by the ch-T131 I-radiolabelling method.Its distribution andimage were detected in the nude mice bearing human liver cancer BEL-7402.Injecting 200 1 131 I-McAbJH107 to each mouse peritoneally the con-centrating of the radioactive substance at the site of the tumor began at24th and strengthened progressively, and reached its top at 96th.Theclearer image of tumor tissue was kept to 148th.At the same time,theradioactive background of the tissues around the tumor gradually disappea-red.In131I-NIgG of the control group well-distributed in the whole body,no signiFicant concentration and no clear image were observed.At 48 and96th, T/NT mean values of 131I-McAbJH107 in normal tissues of 12 kinds(except the brain ) were 3.38 and 6.26 respectively, and ones of 131I-NIgGwere lower than 1.0福建省计委、卫生厅”八五”科技攻关资
