为探讨丝裂霉素C实验性血管外漏致皮肤溃疡的防护措施，我们以0.1Mg丝裂霉素C皮下注射bAlb/C小鼠后腿部，制成丝裂霉素C血管外漏性皮肤溃疡模型。在这模型上经8种不同药物或物理措施单独处理后10天所产生的皮肤溃疡面积与对照组（生理盐水封闭）相比较（经T检验后），差异有显著性的组分别是：外漏后及时用0.1Ml99%二甲基亚砜局部封闭或加用它在外漏表皮处外涂（P＜0.001），0.1Ml5%碳酸氢钠（P＜0.001），0.1Ml1%普鲁卡因（内含0.4%地塞米松）（P＜0.001），0.1Ml90%二甲基亚砜（内含10%维生素E）外涂（P＜0.01）；外漏后半小时用0.1Ml99%二甲基亚砜封闭所产生的皮肤溃疡面积与对照组相比虽有显著差异（P＜0.05），但溃疡防护能力较差。冰水冷敷或0.1Ml10%硫代硫酸钠（及时封闭）组与对照组相比差异无显著性（P＞0.05）。本研究为临床上丝裂霉素C血管外漏的防护提供了药物选择的依据，文中还讨论了二甲基亚砜对丝裂霉素C外漏性皮肤溃疡防护的机理。in order to make an investigation on skin ulcer induced by Mitomycin C extravasation, the preventive measures were undergone by the Following ex-periment.A subcutaneous ulcerative model induced by 0.1mg Mitomycin C(MMC)extravasation in the leg of BALA/C mice was established.On the model subject, 8 pharmacologic adjuvants or physical modulation were adopted.It is preFerential to choose local injection with 0.1ml 99% dimethyl sulFoxide(DMSO),or with additional smearing DMSO on the aFFected skin.10 days later, the ulcerative areas with DMSO treatment were signiFicantly decreased in contrast with 0.1 ml 0.9% NaCI treatment (P0.05) .The mechanisms of prevention of MMC extravascular ulcer by DMSO or 5%NaHCO3 were brieFly discusse
