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结核分枝杆菌相关γ-干扰素体外释放试验在结核病诊断中的应用价值
Authors
吕松琴
张军
+4 more
朱莉莉
李晓非
汪亚玲
熊俊辉
Publication date
1 January 2011
Publisher
Abstract
目的探讨结核分枝杆菌相关γ-干扰素体外释放试验(Tb-IgrA)在结核病诊断中的应用价值。方法用国产Tb-IgrA试剂定量检测268例结核病患者和104例体检健康者外周血结核特异性γ-干扰素的含量,同时与澳大利亚QfT-gIT试剂和结核菌素纯化蛋白质衍生物(PPd)皮试进行平行比较分析。结果国产Tb-IgrA试剂、QfT-gIT试剂和PPd皮试3种方法的敏感性分别为90.7%、88.1%和75.4%,特异性分别为76.9%、80.8%和54.8%,阳性预测值分别为91.0%、92.2%和81.1%,阴性预测值分别为76.2%、72.4%和46.3%,准确性分别为86.8%、86.0%和69.6%。三种方法对肺结核与肺外结核的检测效果无显著差异。结论 Tb-IgrA法对诊断结核病有较高的敏感性和准确性,在结核病防控中有较好的应用价值。国家十一五“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项资助项目(2008ZX10003-004
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Last time updated on 16/06/2016