本文研究大剂量胸腺肽联合干扰素对慢性乙肝患者的治疗作用，发现胸腺肽联合干扰素治疗三个月后，患者的AlT复常率、HbEAg转阴率、HbVdnA阴转率和HbVdnA有效下降率分别为760%、440%、560%和960%。T淋巴细胞亚群分析结果表明，联合治疗后，患者外周血Cd4＋淋巴细胞亚群上调，Cd8＋亚群下调，二者比值趋于正常，说明国产胸腺肽联合干扰素治疗慢性乙肝的治疗机理与免疫调节作用有关。The purpose of this paper was to observe the effects o f clinical treatment of chronic hepatitis B by national thymosin plus interferon α1b and study its machanisms.The parameters of HBV-M,HBV DNA and CD-antigens of T cells were detected by ELISA,PCR and immunochemical dying assay after three m onths of the thymosin treatment.The rates of normal-turning of ALT,negative-turn ing of HBeAg,negative-turning of HBV DNA, and effective downing of HBV DNA in pa tients with chronic hepatitis B were 76.0%,44.00%,56.0%,and 96.0%,respectively.A t the same time,T CD4 + cells in the peripheral blood of patients was up-regula ted,T CD8 + was down-regulated;and ratio of CD4 +/CD8 + is tend to be normal, indicating that its mechanism of thymosin plus interferon α1b in the treatment of chronic hepatitis B may be related to immuno-regulation.厦门市科委资
