变构效应是生命体实现复杂生理效应的精妙调控和准确表达的重要途径.本研究利用双硫键的光致翻转特性,以双硫键为变构“枢纽“单元,设计、合成了一种具有非线性响应的光驱动变构荧光分子探针.合成的分子探针dSSb经过光照后,因双硫键翻转而形成刚性的分子内氢键网络,探针溶液的荧光显著增强;同时,由于阴离子的氢键活性,f-、ACO-和H2PO4-等阴离子的存在将促使氢键网络重组而呈现出不同的荧光响应.因此,该探针可实现对3种阴离子的分辨性荧光传感,并具有非线性响应的特性.Allosterism is an important strategy for accurate regulation and expression of complex physiological effects.Taking advantage of the light-driven rotation activity of disulfide bond,a novel allosteric fluorescent probe is developed based on a disulfide receptor.After irradiation,the probe(DSSB)displays remarkable fluorescence enhancement in solution due to the formation of intramolecular hydrogen-bonding networks.Furthermore,the addition of different anions,such as F-,CH3COO-and H2PO4-,will result in different fluorescence responses due to their characteristic disturbances on the hydrogen-bonding format.All the three anions can be recognized by the probe with nonlinear fluorescent responses.国家自然科学基金(21175113
