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Effects and Mechanism of ephrinB2 on fas ligand Induced Apoptosis in human Umbilical Vein endothelial Cells

Abstract

研究背景:最近随着分子生物学深入到心血管病的研究,大量资料层出不穷,纷纷表面内皮细胞(VECs)凋亡可能通过多种途径启动并加速动脉粥样硬化(AS)的发生,发展过程。该凋亡途径主要通过死亡通路诱导的,死亡配体与受体组成死亡受体系统,二者的结合导致靶细胞走向灭亡。因此,防止VECs凋亡,修复受损的VECs可以减缓初期AS进一步发展,保护VECs的药物也助于预防并治疗早期AS。ephrinB2作为一种促血管生成作用的生长因子,可能在VEGF信号通路中扮演一个总调控者的角色,并在血管生成中发挥核心作用。心梗动物模型显示,EphrinB2蛋白治疗能够抑制多种细胞凋亡,尤其是血管内皮细胞明显增多,促进血管...Background: in recent years, with the study of molecular cardiology in depth, research increasingly suggests that the vascular endothelial cell (VEC) apoptosis and AS in the occurrence, development process, Fas protein and Fas ligand of Fas system, the combination of the two leading to target cell destruction. A number of studies have shown that, AS endothelial cell apoptosis through Fas pathway i...学位:医学硕士院系专业:医学院_内科学学号:2452011115331

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