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Expression and Function of SLC25A38 gene in Acute Lymphoblastic Leukemia Cells

Abstract

目的: 急性淋巴细胞性白血病(ALL)是一类造血干细胞来源的恶性克隆性疾病,近年来,靶向杀伤治疗已成为ALL治疗的发展趋势,分析ALL发生机制、寻找新的治疗靶点成为研究热点。溶质转运蛋白家族(solutecarrier,SLC)是细胞内最大的一类转运蛋白家族,主要功能是介导线粒体基质与膜间隙或膜间隙与细胞质之间的溶质转运,为线粒体提供正常运转所需的物质保障。SLC25A38基因定位于染色体3p22,是一种氨基酸载体,初步研究结果证实,SLC25A38蛋白与神经细胞的凋亡和退行有密切联系,在造血器官(胚鼠肝脏和骨髓)中大量表达,可能与造血细胞的增殖分化有关。为了探讨SLC25A38基因对白血病...Objective: Acute lymphoblastic leukemia(ALL) is a malignancy of hematopoietic stem cell origin. In recent years, targeted killing therapy has become the development trend of ALL treatment, analyse the mechanism, searching for new therapeutic targets become a research hotspot of ALL. The solute transport protein family (SLC) is one of the largest class of intracellular transport protein family. It...学位:医学硕士院系专业:医学院_内科学学号:2452011115330

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