肝纤维化是包括不同病因引起的肝炎、脂肪肝、肝硬化以及肝癌等多种肝脏疾病所共有的病变特征。肝纤维化的发生存在反复性，发展具有阶段性；肝纤维化可视为复杂的慢性肝病，也可视为轻度肝硬化，是由慢性肝病发展为恶性肝硬化肝癌的过渡和中间状态。 肝纤维化的发生发展进程中：以各型胶原蛋白（collagen，Col）为主的细胞外基质（extracellularmatrix，ECM）累积是肝纤维化发生的本质特征；肝星状细胞（hepaticstellatecell，HSC）的活化是肝纤维化发生的关键；结缔组织生长因子（connectivetissuegrowthfactor，CTGF）是肝纤维化发生的“开关”，转...Liver fibrosis, as common pathological changes, can be seen among variety of liver diseases, including hepatitis caused by different factors, fatty liver, cirrhosis of the liver and hepatocellular carcinoma. It has characteristics of periodic and repeatability; the slight liver fibrosis can be considered as liver inflammations, and severe liver fibrosis will worsen into cirrhosis and primary live...学位：理学硕士院系专业：医学院基础医学系_微生物学学号：2452010115332
