背景和目的：随着饮食结构和生活方式的改变，脂肪性肝病在人群中的发病率呈上升趋势。临床中很多时候不得不对合并脂肪变性的肝脏行手术治疗。不断有文献报道脂肪肝增加肝脏手术的并发症和死亡率，但确切的机制至今仍不清楚。本研究旨在从实验和临床两方面探讨肝脏脂肪变性对肝脏部分切除术（PH）安全性及预后的影响。 方法：（1）实验部分：预实验通过8w高脂饲料喂养SD大鼠，构建大鼠脂肪肝模型，并通过病理明确脂肪肝程度。重度脂肪肝模型构建成功后，采用改良的Higgins和Anderson法行70%肝部分切除术，并行第一肝门阻断10min。分别于术前及术后6h、12h、24h、48h、72h处死大鼠，取血液及肝组织...Backgroud：Due to the changes in diet and lifestyle,more and more people were suffering from fatty liver disease. Some authors reported that patients with severe steatosis had an increased risk of inflammatory complications after liver resection, however, the exact mechanism remained unclear. This might be attributable to Kupffer cell-mediated inflammation in steatotic livers causing progressive in...学位：医学硕士院系专业：医学院_外科学学号：2452011115334
