【背景和目的】免疫微环境在肺癌的侵袭转移过程中起着重要作用，TNF-α和IL-6作为两种重要的促炎因子，参与了免疫、炎症反应及肿瘤发生发展的全过程，为肿瘤相关炎症的关键调节分子且可通过上调p38、ERK、NF-κB通路诱导MMPs的表达最终促进肿瘤细胞的侵袭和迁移，但这一机制在肺癌中尚不明确。ATM作为DNA损伤信号传导通路中最早的传感和中枢调控基因，可以多种途径激活NF-κB，从而调控下游靶基因的表达。此外，最近研究发现TGF-β1可激活ATM调控乳腺癌细胞的迁移。这些研究表明，ATM除参与DNA损伤修复外，还与肿瘤细胞的转移相关。因此，炎症因子TNF-α、IL-6对肺癌细胞迁移能力的影响及...Inflammation was reported to have close relationship with carcinogenesis and metastasis. As the important proinflammatory cytokines, TNF-alpha and IL-6 are involved in lung cancer development. ATM, which is activated by DNA double break, was found to be activated by the treatment with TNF-alpha and IL-6, but the exact roles of ATM activation in proinflammatory cytokines such as TNF-alpha and IL-6 ...学位：理学硕士院系专业：医学院_微生物学学号：2452011115339
