β--淀粉样蛋白（Amyloidβ，Aβ）在脑内的渐进性聚集和沉积在阿尔茨海默病（Alzheimer’sdisease，AD）的发病过程中起着至关重要的作用。Aβ是由β-分泌酶（β-secretase）和γ-分泌酶（γ-secretase）对β-淀粉样前体蛋白（Amyloid-βPrecursorProtein，APP）顺序剪切后产生的。这种剪切途径为APP的淀粉样蛋白途径（amyloidogenicpathway）。此外，APP还可以经历非淀粉样蛋白途径（non-amyloidogenicpathway）。在此过程中，APP首先由α-分泌酶（α-secretase）在Aβ中间切割，抑制Aβ产...The progressive aggregation and deposition of amyloid-beta (Amyloid-β, Aβ) peptide in the brain plays an important role in the pathogenesis of Alzheimer's disease (AD). Aβ is generated from the Amyloid-β precursor protein (APP) through sequential proteolytic cleavages by β-secretase (β-site APP cleaving enzyme 1, BACE1) and γ-secretase during the amyloidogenic pathway. Alternatively, APP can be su...学位：理学博士院系专业：药学院_化学生物学学号：3052010015393
