多氯联苯（PolychlorinatedBiphenyls，PCBs）是首批列入斯德哥尔摩公约的持久性有机污染物之一，其引起的环境问题已受到极大关注。虽然有研究表明持久性有机污染物与糖尿病和胰腺癌等胰腺疾病有关，但关于PCBs对胰腺毒性效应的机制研究仍然缺乏。本研究以C57BL/6品系青春期雄性小鼠为研究对象，以商品化的Arocolr1254为PCBs代表，研究环境水平的PCBs暴露对胰腺外分泌部的毒性影响。实验采用浓度分别为0.5、5、50和500μg/kg的Aroclor1254，通过灌胃法对小鼠进行染毒，每三天灌胃一次，暴露持续50天。取得胰腺样品后采用TUNEL方法和Westernbl...Polychlorinated biphenyls (PCBs) are typical persistent organic pollutants (POPs), and they are the first batch members of Convention of Stockholm. PCBs cause many environmental problems and threaten human health, so many researches have been carried out in this field, and some researches have found the relationship between POPs and pancreatic diseases, but research about the effects of PCBs on pa...学位：理学硕士院系专业：生命科学学院_动物学学号：2162010115227
