HIV感染频繁导致HIV相关神经认知紊乱（HIV-AssociatedNeurocognitiveDisease,HAND）。我们已经证明了星形胶质细胞EAAT-2（excitatoryaminoacidtransporter2）表达低下是导致HAND中胞外谷氨酸浓度过高诱导神经元凋亡的关键因素，然而其分子机制尚未阐明。在本实验中，我们使用双重免疫组织化学染色发现：在SIV感染恒河猴大脑皮质EAAT-2减少的部位出现星形胶质细胞和神经元凋亡，并且，在EAAT-2减少部位检测到SIV-1Tat，提示SIV-1Tat可能与EAAT-2表达低下相关。我们发现，在SIV感染恒河猴大脑皮质IL-1β表达...Human immunodeficiency virus (HIV) infection frequently results in neurological damage, such as a HIV-associated neurocognitive disorders (HAND).Our previous study prompts that decreased excitatory amino acid transporter 2 (EAAT-2) on the astrocytes accompanied with high levels of glutamate in the synaptic cleft is a key factor responsible for neuronal damage in the process of HAND. However, the u...学位：理学硕士院系专业：医学院_药理学学号：2452011115330
