Pathomorphological analysis pancreas in different forms pancreatic necrosis

Abstract

An experimental study was performed on 120 white Wistar "rats" Animals were divided into 4 groups, each group of 30animals. When creating models of the CES, flowing mainly on the type of fat pancreatic necrosis was carried out with twopathogenic FACT (ductal hypertension and activation of phospholipases). The dynamics of development of progressive fattypancreatic necrosis with marked cellular infiltration, formation of infiltration, the inflammatory reaction. In the secondseries of experiments using crystalline trypsin shows the evolution of hemorrhagic pancreatic necrosis with involvement ofvisceral organs, hemodynamic shock, DIC, as a result of uncontrolled proteolysis. Our studies allow us to consider the fat andhemorrhagic pancreatic necrosis as different morphological units that must be considered in clinical practice</jats:p