目的 研究miR-145在不同生长方式胃癌中对迁移和侵袭的调节作用及其分子机制，旨在从新的视角探讨胃癌发生发展机制，为寻找新的胃癌目标靶点奠定理论基础。 方法 1.胃癌组织标本中miR-145与FSCN1的表达 收集浸润型和膨胀型胃癌组织标本各40例及其相应的癌旁非肿瘤组织标本，应用RT-PCR检测miR-145与FSCN1的表达水平；应用Westernblot检测FSCN1的蛋白表达水平，统计分析miR-145与FSCN1表达的相关性，结合Ming氏分型比较两种分型中miR-145与FSCN1表达差异。 2.检测miR-145对FSCN1的调控作用 通过TargetscanmiR...Extensive research have revealed that miRNAs plays as an important role in the regµlation of gene expression in the oncogenesis and development of malignant tumor. The previous studies have found that miR-145 was down-regµlated in the stomach neoplasm and it was closely related to tumor migration and invasion. But the molecµlar mechanism of miR-145 in gastric cancer is still uncl...学位：医学硕士院系专业：医学院_外科学学号：2452011115330
