国内外研究表明,胸腺素a原(ProTa)具有调节免疫系统、抗氧化、抗感染、抗炎症、抗凋亡、促进细胞分裂、增殖的功能,这为我们开展ProTa在正常、糖尿病(diabetesmellitus,DM)鼠皮肤受创后的作用及机理的研究提供了理论依据。 基质金属蛋白酶-9(MMP-9)是一种IV型胶原酶,在急性伤口的早期愈合过程中高表达随后下降至正常水平,在整个伤口愈合中发挥着巨大的作用。组织金属蛋白酶抑制剂-1(TIMP-1)是MMP-9的特异性抑制剂,在许多细胞因子的分泌和增殖中作用很大。 Nrf2是调控细胞对抗外来异物和氧化损伤的关键转录因子,可以保护机体免受由高糖高脂引起的氧化损伤。Nrf2的...Researches both at home and abroad shows that Prothymosin alpha (ProTa) plays a great role in regulating the immune system, antioxidant, anti-apoptosis, resistance to infection and inflammation, that it can promote cell division and proliferation, all of which provides a theoretical basis for us to begin our work which refers to the role and mechanism of ProTa in normal mice and DM mice after skin...学位:理学硕士院系专业:生命科学学院生物学系_水生生物学学号:2172009115212