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Preliminary studies on the expression and relationship of CRM1 with EGFR in human glioma

Abstract

背景及目的 人脑胶质细胞瘤是中枢神经系统最常见的恶性肿瘤,发病率明显高于其他颅内肿瘤,手术难以全切,且易复发、预后差。传统治疗方法包括手术切除、放射治疗、化学治疗和免疫治疗,但疗效有限。在目前治疗条件下,胶质瘤病人从确定诊断后生存时间超过5年的不到50%,导致这种疗效不理想的根本原因可归于对其发病机制尚未充分的阐明。近年来,随着分子生物学、分子遗传学的发展,人们对脑胶质瘤的发生发展有了很深的认识。研究已经证实,肿瘤的发生发展、生长及侵袭与很多基因的相互作用有关,胶质瘤也不例外。CRM1,EGFR是近几年研究热点,与脑胶质瘤的发生发展密切相关。我们研究了8例正常脑组织和75例脑胶质瘤标本中CR...Objective: The glioma is the most common malignant tumor in the central nervous system, and the incidence of gliomas is significantly higher than other intracerebral tumors, and it is not easy to cure through surgery, and easy to recurrence with poor prognosis. Traditional treatment methods, including surgical resection, radiotherapy, chemotherapy and immune therapy, have not satisfactory therapeu...学位:医学硕士院系专业:医学院临床医学系_外科学学号:2452009115296

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