老年性痴呆症,即阿尔茨海默病(Alzheimer’sDisease,AD)是发生于老年人群中的一种神经系统退行性疾病,表现为进行性记忆障碍、精神和行为异常、生活自理能力丧失。随着人口老龄化现象日益明显,AD也成为近年来世界各国关注的焦点。虽然目前有关AD的发病机制、基因定位、诊断和治疗等方面取得一定进展,但仍有许多未知领域有待于进一步探索。 流行病学研究显示,阿尔茨海默病在吸烟人群中的发病率较低,且发病时间延迟。AD患者脑组织中的尼古丁受体明显减少,事实也证明尼古丁受体在AD的发病中发挥重要作用,提示作为烟碱型乙酰胆碱受体激动剂的尼古丁可能对AD发病具有保护作用。大量的前期研究表明,尼古丁能...The senile dementia,which is also called Alzheimer’s Disease or AD,is a degenerative disease of nervous system occurring to the old persons, characterized by progressive memory impairment, the spirit and behavior abnormalities. Along with people get longer life than ever, AD is emerging as a major problem of society. Although some progresses have achieved in pathogenesis, gene location, diagnosis...学位:理学硕士院系专业:医学院基础医学系_微生物学学号:2452009115300