目的:探究非诺贝特对PAN诱导肾小球足细胞损伤的作用及作用机制。方法：将18只8周龄SD雌性大鼠随机分为三组(n=6)。PAN模型组和非诺贝特组一次尾静脉注射PAN65mg/mg，空白对照组注射生理盐水，PAN注射后第一天，非诺贝特组灌胃非诺贝特40mg/（kg•d），空白对照组和PAN模型组灌胃等体积溶剂。分别于D0、D6、D10收集24小时尿样，采用Bradford法测定大鼠24h尿蛋白含量。PAN注射后10天杀死大鼠,收集肾小球样本。利用Westernblotting和Real-TimePCR检测肾小球足细胞损伤标记物的表达和凋亡相关基因、骨架蛋白以及裂隙膜蛋白基因转录活性。...Objective： To investigate the function of fenofibrate on PAN-induced podocyte injury. Method: 18 weeks old SD female rats were randomly assigned into 3 group( n=6). mice in PAN group and fenofibrate treated group received a single intravenous injection of PAN（65 mg／kg）, while those in control group received equal volume of saline. Mice in fenofibrate treated group received 40 mg／（kg•d） of fe...学位：理学硕士院系专业：医学院_药理学学号：2452011115340
