研究背景和目的 在日照丰富的国家，皮肤癌的患病率极高，其病因复杂，发病机制各异，而传统的放疗、化疗手段存在抗肿瘤效果差、副作用大等一系列缺点。分子靶向治疗却有着良好的肿瘤靶向性和较低的毒副作用，为癌症治疗提供了新的治疗手段。近期研究显示神经鞭毛素蛋白-1（Neuropilin-1，NRP-1)是癌症治疗的新靶标，NRP-1是一个新型的多功能受体，是Ⅰ型跨膜糖蛋白。NRP-1可作为轴突导向因子3(semaphorin3，Sema3）、血管内皮细胞因子（vascularendothelialgrowthfactor，VEGF）、肝细胞生长因子（hepatocytegrowthfactor，HGF...Background and Purpose In the abundant sunshine state, the morbidity rate of skin cancer is extremely high, its etiology is complex and pathogenesis is different. But traditional radiotherapy and chemotherapy are used in a restrict range for the disadvantages of low effects and large side effects. Molecular targeted drugs with high tumor-targeting ability and low side effects provide a new strat...学位：理学硕士院系专业：医学院_药理学学号：2452011115336
