目的：联合阻断效应性T细胞(effectorTcell)与记忆性T细胞(memoryTcell，Tm)诱导记忆性心脏移植的供者特异性耐受，探讨各种记忆性细胞在记忆性心脏移植中发挥作用的机制。 方法：首先通过同种异体皮肤移植得到预致敏小鼠，过继转移同种反应性记忆性T细胞，构建小鼠同种异体心脏移植模型后再联合阻断效应及记忆性T细胞激活途径，观察移植物生存期的改变，并从移植物和模型鼠两个角度探讨其可能的作用机制；之后以同种异体皮肤移植预致敏小鼠为受体进行心脏移植(二次移植模型)，联合应用anti-CD40L、anti-LFA-1、anti-OX40L和/或anti-CD122治疗并观察其生存期。采...Background：Donor-reactive memory T cells threaten the survival of transplanted organs via multiple pathways. However, the effect of costimulatory blockade in secondary allograft rejection has not been studied. Materials and methods：The first part of this study was undertaken to induce tolerance of cardiac allografts in mice, in which alloreactive memory T cells were adoptively transferred, by com...学位：医学硕士院系专业：医学院临床医学系_外科学学号：2452007115252
