大脑内具有神经毒性的β-淀粉样蛋白（Aβ）的累积在阿尔兹海默症（Alzheimer’sdisease，AD）的发病过程中处于中心地位。Aβ是由β-分泌酶和γ-分泌酶对β-淀粉样前体蛋白（β-amyloidprecursorprotein，APP）顺序剪切后产生的。β-位点APP剪切酶1（β-siteAPPcleavingenzyme1，BACE1）被认为是主要的β-分泌酶，并与AD密切相关。尽管关于BACE1的调节和功能还不十分清楚，但研究表明BACE1主要定位于Golgi/TGN以及内含体等酸性细胞器中，这些细胞器能为BACE1的活性提供最佳pH。因此，BACE1的亚细胞定位在很大程度上会影...Accumulation of the neurotoxic β-amyloid (Aβ) peptide in the brain is central to the pathogenesis of Alzheimer's disease (AD). Aβ is derived from sequential cleavages of β-amyloid precursor protein (APP) by β- and γ-secretases. β-site APP cleaving enzyme 1 (BACE1), which is considered the major β-secretase, is closely linked to AD. Although the regulation and functions of BACE1 have not been fully...学位：理学博士院系专业：药学院_化学生物学学号：3052009015359
