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Predictive Value of P-glycoprotein Expressed in Peripheral Blood in Drug Resistant Epilepsy

Abstract

目的:通过分析耐药性癫痫患者的临床特点,探讨耐药性产生的危险因素。检测外周血P糖蛋白(p-glycoprotein,P-gp)相关指标,寻找能够预测患者耐药性的实验室指标,并评价这些指标在筛选耐药性癫痫时的应用价值。 方法:整理癫痫患者资料92例,耐药性癫痫患者和控制良好癫痫患者各46例,每组男女各23例。统计分析两组患者起病年龄、病程、发作类型、是否有病灶、是否有颞叶异常放电、是否有脑炎病史6个基本临床指标,用Logistic回归计算这些指标在评估癫痫患者耐药性时的价值。从两组患者中筛选出没有病灶的患者,统计分析两组无病灶患者之间临床特点的差异,并计算这些临床指标在评估癫痫患者耐药性时的价...Purpose: Analysis the clinical characters of drug resistant epilepsy. Investigate the expression of P-glycoprotein (P-gp), which is product of multidrug resistance gene 1 (MDR1), in peripheral blood. And evaluate whether P-gp expression on blood cells is a useful indication in diagnosis of drug resistant epilepsy. Methods: This study enrolled 46 patients of drug with drug resistance epilepsy and...学位:医学硕士院系专业:医学院临床医学系_内科学学号:2452009115295

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