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Comparative study of large yellow croaker (Pseudosciaena crocea) and marine medaka (Oryzias melastigma) Hepcidin gene expression and peptide functions

Abstract

抗菌肽是一类从生物体中分离的小分子多肽,具有抗细菌,真菌,病毒,肿瘤和寄生虫等多种作用。由于抗菌肽来源于生物体本身,同时病原菌不易对其产生耐药性,所以被视为一种极有潜力的抗生素的替代品。Hepcidin抗菌肽是鱼类抗菌肽家族中的重要一种,鱼体内的Hepcidin更是鱼类先天免疫因子的重要组成部分。本研究运用分子生物学技术对养殖鱼类大黄鱼(Pseudosciaenacrocea)Hepcidin和模式动物海水青鳉(Oryziasmelastigma)Hepcidin的基因表达特性与功能进行了比较研究和探讨,主要研究成果如下: 1. 克隆获得了源于海水养殖大黄鱼Hepcidin(Pc-hepc)...Antimicrobial peptides (AMPs) are a group of small peptides amplified from organisms which have anti-bacterial activity, anti-fungi activity, anti-virus activity, anti-tumors activity, etc. AMPs are thought to be very good substitutes for antibiotics that they can defense pathogens invading with less drug tolerance for they are derived from organism themselves. Hepcidin is an important AMP family,...学位:理学博士院系专业:海洋与环境学院环境科学与工程系_环境科学学号:2262007015392

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