抗菌肽(antimicrobialpeptide)是一类具有广谱抗微生物活性的天然小肽类物质，是先天免疫系统中重要的非特异性免疫因子。Hepcidin是2000年首先从人类中发现的一类富含半胱氨酸、性质独特的抗菌肽，其不仅具有显著的抗微生物活性，还被认为是一种关键的铁代谢调节因子，在鱼类中分布广泛。本论文以我国重要的海水经济养殖鱼类－真鲷(Pagrusmajor)和黑鲷（Spagrusmacrocephalus）为研究对象，较深入的研究了hepcidin抗菌肽的基因结构组成、器官、组织特异性分布、体外表达及其表达产物的抗菌活性，为开发应用hepcidin抗菌肽奠定基础。通过研究获得了如下结果：...As a major part of immediately effective, nonspecific defenses against infections, antimicrobial peptides (AMPs) play a crucial role in the innate immune system. Hepcidin is a circulating antimicrobial peptide and putative iron regulatory hormone previously described in mice and humans. There are several species of fish hepcidins that have been isolated and characterized so far. It was speculated ...学位：理学博士院系专业：海洋与环境学院海洋学系_海洋生物学学号：B20032700
