Driven by the multi-level structure of human intracranial
electroencephalogram (iEEG) recordings of epileptic seizures, we introduce a
new variant of a hierarchical Dirichlet Process---the multi-level clustering
hierarchical Dirichlet Process (MLC-HDP)---that simultaneously clusters
datasets on multiple levels. Our seizure dataset contains brain activity
recorded in typically more than a hundred individual channels for each seizure
of each patient. The MLC-HDP model clusters over channels-types, seizure-types,
and patient-types simultaneously. We describe this model and its implementation
in detail. We also present the results of a simulation study comparing the
MLC-HDP to a similar model, the Nested Dirichlet Process and finally
demonstrate the MLC-HDP's use in modeling seizures across multiple patients. We
find the MLC-HDP's clustering to be comparable to independent human physician
clusterings. To our knowledge, the MLC-HDP model is the first in the epilepsy
literature capable of clustering seizures within and between patients.Comment: ICML201
